2024
mosGILT controls innate immunity and germ cell development in Anopheles gambiae
Arora G, Tang X, Cui Y, Yang J, Chuang Y, Joshi J, Sajid A, Dong Y, Cresswell P, Dimopoulos G, Fikrig E. mosGILT controls innate immunity and germ cell development in Anopheles gambiae. BMC Genomics 2024, 25: 42. PMID: 38191283, PMCID: PMC10775533, DOI: 10.1186/s12864-023-09887-0.Peer-Reviewed Original ResearchConceptsGerm cell developmentAnopheles gambiaeCell developmentOvarian developmentReductase-like proteinWild-type mosquitoesPlasmodium life cycleBiological controlGrowth genesEssential regulatorRNA sequencingA. gambiaeGenesGambiaeAltered expressionImpaired ovarian developmentMosquito vectorsLife cycleMosquitoesImmune activationPlasmodium infectionTranscriptomeOogenesisRegulatorProtein
2020
Analysis of blood-induced Anopheles gambiae midgut proteins and sexual stage Plasmodium falciparum interaction reveals mosquito genes important for malaria transmission
Cui Y, Niu G, Li VL, Wang X, Li J. Analysis of blood-induced Anopheles gambiae midgut proteins and sexual stage Plasmodium falciparum interaction reveals mosquito genes important for malaria transmission. Scientific Reports 2020, 10: 14316. PMID: 32868841, PMCID: PMC7459308, DOI: 10.1038/s41598-020-71186-5.Peer-Reviewed Original ResearchConceptsMidgut proteinsCandidate genesStage parasitesGene expression profilesMosquito genesUnique genesMalaria transmissionInsect cellsMosquito proteinsSexual stage parasitesGene productsAsexual stage parasitesKnockdown assaysP. falciparum invasionProtein sequencesPlasmodium invasionAnopheles gambiaeSecretory proteinsExpression profilesMosquito midgutParasite invasionGenesCell lysatesMosquito susceptibilityProtein