2010
Glutathione deficient C57BL/6J mice are not sensitized to ozone-induced lung injury
Johansson E, Wesselkamper SC, Shertzer HG, Leikauf GD, Dalton TP, Chen Y. Glutathione deficient C57BL/6J mice are not sensitized to ozone-induced lung injury. Biochemical And Biophysical Research Communications 2010, 396: 407-412. PMID: 20417186, PMCID: PMC2892220, DOI: 10.1016/j.bbrc.2010.04.105.Peer-Reviewed Original ResearchConceptsOzone-induced lung injuryGlutamate-cysteine ligase modifier subunitLung injuryLung hyperpermeabilityDegree of neutrophiliaBronchoalveolar lavage fluidWild-type miceInflammatory gene expressionPulmonary susceptibilityLavage fluidCompensatory augmentationKnockout miceTotal protein concentrationPpm ozoneMiceModifier subunitMRNA levelsAntioxidant defenseMember 2Antioxidant glutathioneMetallothionein-1GSH depletionHyperpermeabilityInjuryAntioxidant response
2008
Generation of a ‘humanized’ hCYP1A1_1A2_Cyp1a1/1a2(−/−)_Ahrd mouse line harboring the poor-affinity aryl hydrocarbon receptor
Shi Z, Chen Y, Dong H, Amos-Kroohs RM, Nebert DW. Generation of a ‘humanized’ hCYP1A1_1A2_Cyp1a1/1a2(−/−)_Ahrd mouse line harboring the poor-affinity aryl hydrocarbon receptor. Biochemical And Biophysical Research Communications 2008, 376: 775-780. PMID: 18814841, PMCID: PMC2582963, DOI: 10.1016/j.bbrc.2008.09.068.Peer-Reviewed Original ResearchConceptsHigh-affinity aryl hydrocarbon receptorAryl hydrocarbon receptorDose-response curveMouse linesHydrocarbon receptorCYP1A2 geneHuman risk assessmentC57BL/6J miceNew mouse lineDBA/2J miceCYP1A2 substratesMiceCYP1A2 mRNACYP1A1Mouse CYP1A1Human CYP1A1ReceptorsFunctional CYP1A1Vast majorityRisk assessmentLungKidney