2016
ALDH3A1 Plays a Functional Role in Maintenance of Corneal Epithelial Homeostasis
Koppaka V, Chen Y, Mehta G, Orlicky DJ, Thompson DC, Jester JV, Vasiliou V. ALDH3A1 Plays a Functional Role in Maintenance of Corneal Epithelial Homeostasis. PLOS ONE 2016, 11: e0146433. PMID: 26751691, PMCID: PMC4708999, DOI: 10.1371/journal.pone.0146433.Peer-Reviewed Original ResearchConceptsCorneal cell proliferationCorneal epithelial homeostasisCell proliferationALDH3A1 expressionEpithelial homeostasisHuman corneal epithelial cell lineDouble knockout miceAnti-proliferation effectCorneal epithelial cell lineCorneal epithelial proliferationAldehyde dehydrogenase 1A1Epithelial cell lineCorneal differentiation markersInner ocular tissuesInverse associationFunctional roleEpithelial proliferationKnockout miceP53 expressionCorneal epitheliumOcular tissuesMouse corneaCalcium concentrationMRNA levelsEpithelial differentiation
2010
Glutathione deficient C57BL/6J mice are not sensitized to ozone-induced lung injury
Johansson E, Wesselkamper SC, Shertzer HG, Leikauf GD, Dalton TP, Chen Y. Glutathione deficient C57BL/6J mice are not sensitized to ozone-induced lung injury. Biochemical And Biophysical Research Communications 2010, 396: 407-412. PMID: 20417186, PMCID: PMC2892220, DOI: 10.1016/j.bbrc.2010.04.105.Peer-Reviewed Original ResearchConceptsOzone-induced lung injuryGlutamate-cysteine ligase modifier subunitLung injuryLung hyperpermeabilityDegree of neutrophiliaBronchoalveolar lavage fluidWild-type miceInflammatory gene expressionPulmonary susceptibilityLavage fluidCompensatory augmentationKnockout miceTotal protein concentrationPpm ozoneMiceModifier subunitMRNA levelsAntioxidant defenseMember 2Antioxidant glutathioneMetallothionein-1GSH depletionHyperpermeabilityInjuryAntioxidant response
2009
Curcumin, quercetin, and tBHQ modulate glutathione levels in astrocytes and neurons: importance of the glutamate cysteine ligase modifier subunit
Lavoie S, Chen Y, Dalton TP, Gysin R, Cuénod M, Steullet P, Q. K. Curcumin, quercetin, and tBHQ modulate glutathione levels in astrocytes and neurons: importance of the glutamate cysteine ligase modifier subunit. Journal Of Neurochemistry 2009, 108: 1410-1422. PMID: 19183254, DOI: 10.1111/j.1471-4159.2009.05908.x.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAntioxidantsAstrocytesCell SurvivalCells, CulturedCerebral CortexCurcuminDose-Response Relationship, DrugEmbryo, MammalianEnzyme InhibitorsGene ExpressionGlutamate-Cysteine LigaseGlutathioneHydroquinonesMiceMice, Inbred C57BLMice, KnockoutNeuronsProtein SubunitsQuercetinUp-RegulationConceptsGlutamate-cysteine ligaseGCL activityRate-limiting synthesizing enzymeRedox regulatorCatalytic subunitGSH levelsGene expressionCysteine ligaseGlutamate cysteine ligase modifierModifier subunitCell deathCell typesGSH synthesisEnzymeNeurodegenerative diseasesCultured neuronsGCLMSubunitsMRNA levelsSynthesizing enzymesGSHLower GSHAbility of curcuminExpressionLigase