Mechanistic considerations in 1,4-dioxane cancer risk assessment
Ginsberg G, Chen Y, Vasiliou V. Mechanistic considerations in 1,4-dioxane cancer risk assessment. Current Opinion In Environmental Science & Health 2022, 30: 100407. PMID: 37091947, PMCID: PMC10120849, DOI: 10.1016/j.coesh.2022.100407.Peer-Reviewed Original ResearchCarcinogenic effectsLinear low-dose extrapolationGenders of ratsDose responseInduction of CYP2E1Human liver cancerCancer risk assessmentLow-dose extrapolationLiver cancerLow doseAnimal studiesDose levelsChronic exposureLow human exposureDose extrapolationCarcinogenic responseStandard test batteryVivo genotoxicityRisk assessmentOxidative stressDisease-related processesOwn metabolismLess likelihoodMode of actionHuman exposureOxidative stress, glutathione, and CYP2E1 in 1,4-dioxane liver cytotoxicity and genotoxicity: insights from animal models
Wang Y, Charkoftaki G, Davidson E, Orlicky D, Tanguay R, Thompson D, Vasiliou V, Chen Y. Oxidative stress, glutathione, and CYP2E1 in 1,4-dioxane liver cytotoxicity and genotoxicity: insights from animal models. Current Opinion In Environmental Science & Health 2022, 29: 100389. PMID: 37483863, PMCID: PMC10361651, DOI: 10.1016/j.coesh.2022.100389.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsOxidative stressUnique mouse modelRelevant low dosesDirect genotoxic effectsLiver cytotoxicityCYP2E1 activationMouse modelAnimal modelsHuman studiesCarcinogenic pathwaysLiver carcinogenicityLow dosesCausal roleGenotoxic effectsHuman exposureUndetermined mechanismPublic healthCarcinogenicityLiver genotoxicityDrinking water contaminantsMechanistic dataGenotoxicityFuture animalCytotoxicityCYP2E1