2014
Functional Cardiomyocytes Derived from Isl1 Cardiac Progenitors via Bmp4 Stimulation
Cagavi E, Bartulos O, Suh CY, Sun B, Yue Z, Jiang Z, Yue L, Qyang Y. Functional Cardiomyocytes Derived from Isl1 Cardiac Progenitors via Bmp4 Stimulation. PLOS ONE 2014, 9: e110752. PMID: 25522363, PMCID: PMC4270687, DOI: 10.1371/journal.pone.0110752.Peer-Reviewed Original ResearchConceptsCardiac progenitor cellsCardiac repairProliferative abilityProgenitor cellsCell-based cardiac regenerative therapySignificant therapeutic valueCardiac regenerative therapyAdult cardiac progenitor cellsStem cellsCPC culturesHigh proliferative abilityHeart failureCardiac originCardiac differentiationMyocardial infarctionAnterior heart fieldInduction of Bmp4Leading causePotential treatmentRole of BMP4Therapeutic valueCardiac progenitorsUntreated cardiomyocytesProtein expressionRegenerative therapy
2007
The Renewal and Differentiation of Isl1 + Cardiovascular Progenitors Are Controlled by a Wnt/β-Catenin Pathway
Qyang Y, Martin-Puig S, Chiravuri M, Chen S, Xu H, Bu L, Jiang X, Lin L, Granger A, Moretti A, Caron L, Wu X, Clarke J, Taketo MM, Laugwitz KL, Moon RT, Gruber P, Evans SM, Ding S, Chien KR. The Renewal and Differentiation of Isl1 + Cardiovascular Progenitors Are Controlled by a Wnt/β-Catenin Pathway. Cell Stem Cell 2007, 1: 165-179. PMID: 18371348, DOI: 10.1016/j.stem.2007.05.018.Peer-Reviewed Original Research
1999
Cell-Type-Dependent Activity of the Ubiquitous Transcription Factor USF in Cellular Proliferation and Transcriptional Activation
Qyang Y, Luo X, Lu T, Ismail P, Krylov D, Vinson C, Sawadogo M. Cell-Type-Dependent Activity of the Ubiquitous Transcription Factor USF in Cellular Proliferation and Transcriptional Activation. Molecular And Cellular Biology 1999, 19: 1508-1517. PMID: 9891084, PMCID: PMC116079, DOI: 10.1128/mcb.19.2.1508.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceCell DivisionCell LineDNADNA-Binding ProteinsGene ExpressionGenes, ReporterHeLa CellsHumansImmediate-Early ProteinsModels, BiologicalMolecular Sequence DataRecombinant Fusion ProteinsSubcellular FractionsTrans-ActivatorsTranscription FactorsTranscriptional ActivationTransfectionUpstream Stimulatory FactorsViral Envelope ProteinsConceptsUSF-specific regionDNA-binding activityUSF proteinsSaos-2 cellsTranscriptional activationAutonomous transcriptional activation domainsTranscriptional activityTranscriptional activation domainTranscription factor USFActivity of USFHelix transcription factorCellular proliferationCell linesActivation domainUSF activityUSF functionSaos-2 osteosarcoma cell lineSubcellular localizationTranscription factorsInitiator elementReporter geneMutational analysisTransient cotransfectionFusion proteinOsteosarcoma cell lines