2002
The p21‐activated kinase, Shk1, is required for proper regulation of microtubule dynamics in the fission yeast, Schizosaccharomyces pombe
Qyang Y, Yang P, Du H, Lai H, Kim H, Marcus S. The p21‐activated kinase, Shk1, is required for proper regulation of microtubule dynamics in the fission yeast, Schizosaccharomyces pombe. Molecular Microbiology 2002, 44: 325-334. PMID: 11972773, DOI: 10.1046/j.1365-2958.2002.02882.x.Peer-Reviewed Original ResearchConceptsFission yeastP21-activated kinaseMicrotubule dynamicsMicrotubule spindleProper regulationCell endsFission yeast cellsMicrotubule-destabilizing drug thiabendazoleGreen fluorescent proteinShk1 functionCell polarityKinase functionMutant cellsSpindle defectsShk1Microtubule defectsCold sensitiveDrug thiabendazoleKinase activityInterphase microtubulesFusion proteinYeast cellsPotential regulatorFluorescent proteinRelease of cells
2001
Genetic and Molecular Characterization of Skb15, a Highly Conserved Inhibitor of the Fission Yeast PAK, Shk1
Kim H, Yang P, Qyang Y, Lai H, Du H, Henkel J, Kumar K, Bao S, Liu M, Marcus S. Genetic and Molecular Characterization of Skb15, a Highly Conserved Inhibitor of the Fission Yeast PAK, Shk1. Molecular Cell 2001, 7: 1095-1101. PMID: 11389855, DOI: 10.1016/s1097-2765(01)00248-9.Peer-Reviewed Original ResearchConceptsFission yeastP21-activated kinaseCytokinetic functionCytokinetic machineryCell polarityProtein functionSkb15Cytoskeletal remodelingMouse homologMicrotubule biogenesisShk1Mating responseNegative regulationActin polymerizationNull mutationCell cycleMolecular characterizationYeastSubstantial uncouplingProper executionPartial lossSchizosaccharomycesBiogenesisHomologKinaseThe Highly Conserved Protein Methyltransferase, Skb1, Is a Mediator of Hyperosmotic Stress Response in the Fission YeastSchizosaccharomyces pombe *
Bao S, Qyang Y, Yang P, Kim H, Du H, Bartholomeusz G, Henkel J, Pimental R, Verde F, Marcus S. The Highly Conserved Protein Methyltransferase, Skb1, Is a Mediator of Hyperosmotic Stress Response in the Fission YeastSchizosaccharomyces pombe *. Journal Of Biological Chemistry 2001, 276: 14549-14552. PMID: 11278267, DOI: 10.1074/jbc.c100096200.Peer-Reviewed Original ResearchConceptsHyperosmotic stress responseProtein methyltransferase activityS. pombe cellsFission yeastStress responseCell polarityProtein methyltransferasePombe cellsHyperosmotic stressMethyltransferase activityCell endsSites of septationNormal growth conditionsPrevious genetic studiesP21-activated kinaseEvolutionary conservationProtein methyltransferasesFission YeastSchizosaccharomycesSubcellular targetingSKB1Mating responseShk1F-actinGenetic studiesCell growth