2023
Differences in the immunogenicity of engineered circular RNAs
Tai J, Chen Y. Differences in the immunogenicity of engineered circular RNAs. Journal Of Molecular Cell Biology 2023, 15: mjad002. PMID: 36787893, PMCID: PMC10257478, DOI: 10.1093/jmcb/mjad002.Peer-Reviewed Original ResearchRNARNA, Circular
2022
circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment
Piras R, Ko E, Barrett C, De Simone M, Lin X, Broz M, Tessaro F, Castillo-Martin M, Cordon-Cardo C, Goodridge H, Di Vizio D, Batish M, Lawrenson K, Chen Y, Chan K, Guarnerio J. circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment. Nature Communications 2022, 13: 7243. PMID: 36433954, PMCID: PMC9700836, DOI: 10.1038/s41467-022-34872-8.Peer-Reviewed Original ResearchMeSH KeywordsCarcinogenesisCasein Kinase IHumansInterferonsRNA, CircularSarcomaSoft Tissue NeoplasmsTumor MicroenvironmentConceptsNon-coding RNA speciesExonic circular RNAsViral RNA sensorsRNA speciesInterferon-related genesSpecific circRNAsCircular RNAsSarcoma cellsCircRNAsRNA sensorsCancer progressionFunctional contributionInterferon responseSoft tissue sarcoma cellsImmune cell recruitmentPro-tumorigenic microenvironmentCellsTumor growthSarcoma growthTumor cellsPro-inflammatory elementsCell recruitmentActivationPro-inflammatory factorsMicroenvironment