Encapsulation of an Antioxidant in Redox-Sensitive Self-Assembled Albumin Nanoparticles for the Treatment of Hepatitis
Yasuda K, Maeda H, Kinoshita R, Minayoshi Y, Mizuta Y, Nakamura Y, Imoto S, Nishi K, Yamasaki K, Sakuragi M, Nakamura T, Ikeda-Imafuku M, Iwao Y, Ishima Y, Ishida T, Iwakiri Y, Otagiri M, Watanabe H, Maruyama T. Encapsulation of an Antioxidant in Redox-Sensitive Self-Assembled Albumin Nanoparticles for the Treatment of Hepatitis. ACS Nano 2023, 17: 16668-16681. PMID: 37579503, DOI: 10.1021/acsnano.3c02877.Peer-Reviewed Original ResearchConceptsAlbumin nanoparticlesRedox characteristicsNanoparticlesStable formReactive oxygen speciesAlbumin moleculeIntramolecular disulfide bondsDisulfide bondsIntermolecular disulfide bridgesDisulfide bridgesPreparationNanoantioxidantsBondsNanostructuresOxygen speciesMoleculesEncapsulationHereinNanoscaleAdditivesAntioxidantsSerum conditionsTreatment of hepatitisWater