Increased phosphodiesterase-5 expression is involved in the decreased vasodilator response to nitric oxide in cirrhotic rat livers
Loureiro-Silva MR, Iwakiri Y, Abraldes JG, Haq O, Groszmann RJ. Increased phosphodiesterase-5 expression is involved in the decreased vasodilator response to nitric oxide in cirrhotic rat livers. Journal Of Hepatology 2006, 44: 886-893. PMID: 16545481, DOI: 10.1016/j.jhep.2006.01.032.Peer-Reviewed Original ResearchMeSH Keywords3',5'-Cyclic-GMP PhosphodiesterasesAnimalsCyclic Nucleotide Phosphodiesterases, Type 5Enzyme InhibitorsLiver CirculationLiver CirrhosisMaleNitric OxideNitric Oxide SynthaseOmega-N-MethylargininePhosphodiesterase InhibitorsPhosphoric Diester HydrolasesPiperazinesPurinesRatsRats, Sprague-DawleySildenafil CitrateSulfonesVasodilationConceptsPDE-5 expressionPhosphodiesterase-5 expressionCirrhotic liverCirrhotic rat liverPresence of sildenafilNitric oxideVasodilator responseDeficient responseNormal liverAscitic cirrhotic ratsDecreased vascular responseDecreased vasodilator responseConcentration-response curvesRat liverCyclic guanosine 3Second messenger cyclic guanosine 3Vasodilator effectCirrhotic ratsVascular responsesBACKGROUND/Liver perfusionDecreased responseSpontaneous NO donorSildenafil citrateNO donor