Featured Publications
Covid‐19 and Liver Injury: Role of Inflammatory Endotheliopathy, Platelet Dysfunction, and Thrombosis
McConnell MJ, Kondo R, Kawaguchi N, Iwakiri Y. Covid‐19 and Liver Injury: Role of Inflammatory Endotheliopathy, Platelet Dysfunction, and Thrombosis. Hepatology Communications 2022, 6: 255-269. PMID: 34658172, PMCID: PMC8652692, DOI: 10.1002/hep4.1843.Peer-Reviewed Original ResearchMeSH KeywordsBlood Platelet DisordersCOVID-19Endothelium, VascularHumansInflammationLiver DiseasesThrombosisConceptsLiver injurySARS-CoV-2Severe acute respiratory syndrome coronavirus 2Coronavirus disease 2019 (COVID-19) symptomsAcute respiratory syndrome coronavirus 2Alcohol-related liver diseaseSARS-CoV-2 infectionRespiratory syndrome coronavirus 2Chronic liver failureLiver-related complicationsDirect viral infectionElevated aspartate aminotransferaseSyndrome coronavirus 2COVID-19Pathophysiologic explanationLiver failureLiver diseasePlatelet dysfunctionVascular inflammationInflammatory environmentHepatic effectsAlanine aminotransferaseViral infectionAspartate aminotransferaseHepatic foci
2017
Biology of portal hypertension
McConnell M, Iwakiri Y. Biology of portal hypertension. Hepatology International 2017, 12: 11-23. PMID: 29075990, PMCID: PMC7090883, DOI: 10.1007/s12072-017-9826-x.BooksMeSH KeywordsAnimalsAscitesBlood PlateletsEndothelial CellsEsophageal and Gastric VaricesFibrosisGastrointestinal HemorrhageHepatic EncephalopathyHepatic Veno-Occlusive DiseaseHepatorenal SyndromeHumansHypertension, PortalLiverMiceMicrovesselsModels, AnimalNeovascularization, PathologicRenal InsufficiencySplanchnic CirculationThrombosisVascular ResistanceConceptsLiver sinusoidal endothelial cellsPortal hypertensionMicrovascular thrombosisHepatic stellate cell activationHyperdynamic circulatory syndromeSystemic arterial vasodilationChronic liver diseaseIntrahepatic vascular resistanceSinusoidal portal hypertensionPortal hypertension resultsStellate cell activationSinusoidal endothelial cellsVascular biology researchHepatorenal syndromeGastroesophageal varicesVariceal hemorrhageVascular resistanceArterial vasodilationCirculatory syndromeRenal failureHepatic encephalopathyHypertension resultsLiver diseasePortosystemic shuntMesenteric vasculature
2015
Hepatic congestion leads to fibrosis: Findings in a newly developed murine model
Hidaka H, Iwakiri Y. Hepatic congestion leads to fibrosis: Findings in a newly developed murine model. Hepatology 2015, 61: 428-430. PMID: 25283276, PMCID: PMC4303496, DOI: 10.1002/hep.27550.Commentaries, Editorials and Letters