2021
Nitric oxide facilitates the targeting Kupffer cells of a nano-antioxidant for the treatment of NASH
Maeda H, Ishima Y, Saruwatari J, Mizuta Y, Minayoshi Y, Ichimizu S, Yanagisawa H, Nagasaki T, Yasuda K, Oshiro S, Taura M, McConnell MJ, Oniki K, Sonoda K, Wakayama T, Kinoshita M, Shuto T, Kai H, Tanaka M, Sasaki Y, Iwakiri Y, Otagiri M, Watanabe H, Maruyama T. Nitric oxide facilitates the targeting Kupffer cells of a nano-antioxidant for the treatment of NASH. Journal Of Controlled Release 2021, 341: 457-474. PMID: 34856227, DOI: 10.1016/j.jconrel.2021.11.039.Peer-Reviewed Original ResearchConceptsMannose receptor C type 1Treatment of NASHNonalcoholic steatohepatitisKupffer cellsBlood flowNO donorReactive oxygen speciesHepatic blood flowDevelopment of steatohepatitisNASH model miceC type 1Nitric oxide donorOxidative stress-associated pathologiesStress-associated pathologiesCombination therapyHepatoprotective effectModel miceLiver lobeOxide donorType 2Therapeutic potentialType 1Nitric oxidePathological phenotypesSpecific uptake
2020
The lymphatic system in alcohol-associated liver disease
Kondo R, Iwakiri Y. The lymphatic system in alcohol-associated liver disease. Clinical And Molecular Hepatology 2020, 26: 633-638. PMID: 32951411, PMCID: PMC7641555, DOI: 10.3350/cmh.2020.0179.BooksConceptsAlcoholic liver diseaseLymphatic systemLiver diseaseTreatment of ALDAlcohol-associated liver diseaseAlcohol-related diseasesEffects of alcoholHepatic lymphaticsFluid balanceCell surveillanceTherapeutic potentialImmune cell surveillanceDiseaseInterstitial fluid balanceReview articlePathogenesisLymphatics