2007
Increased neuronal nitric oxide synthase interaction with soluble guanylate cyclase contributes to the splanchnic arterial vasodilation in portal hypertensive rats
Kwon SY, Groszmann RJ, Iwakiri Y. Increased neuronal nitric oxide synthase interaction with soluble guanylate cyclase contributes to the splanchnic arterial vasodilation in portal hypertensive rats. Hepatology Research 2007, 37: 58-67. PMID: 17300699, DOI: 10.1111/j.1872-034x.2007.00005.x.Peer-Reviewed Original ResearchNeuronal nitric oxide synthaseSplanchnic arterial vasodilationPortal hypertensive ratsPartial portal vein ligationSoluble guanylate cyclaseArterial vasodilationHypertensive ratsSmooth muscle layerContractile responseNNOS proteinNNOS inhibitorMuscle layerRole of nNOSSuperior mesenteric arterial bedNNOS-specific inhibitorPortal hypertensive groupPortal hypertensive stateMesenteric arterial bedPortal vein ligationSham-operated groupNitric oxide synthaseActivation of sGCNitric oxide releaseHypertensive groupPortal hypertension
2002
Mice with targeted deletion of eNOS develop hyperdynamic circulation associated with portal hypertension
Iwakiri Y, Cadelina G, Sessa WC, Groszmann RJ. Mice with targeted deletion of eNOS develop hyperdynamic circulation associated with portal hypertension. AJP Gastrointestinal And Liver Physiology 2002, 283: g1074-g1081. PMID: 12381520, DOI: 10.1152/ajpgi.00145.2002.Peer-Reviewed Original ResearchConceptsPartial portal vein ligationEndothelial NO synthaseHyperdynamic circulatory statePortal hypertensive animalsHyperdynamic circulationPortal hypertensionCirculatory stateHypertensive animalsInducible NOSNitric oxideLevels of vasodilatorsPortal vein ligationSham-operated groupSham-operated animalsSystemic vasodilationSplanchnic circulationPeripheral resistanceVein ligationSham animalsNO synthaseKnockout miceGene deletionINOS geneHemodynamic characteristicsMice