2007
Decreased intrahepatic response to α1‐adrenergic agonists in lipopolysaccharide‐treated rats is located in the sinusoidal area and depends on Kupffer cell function
Lee C, Loureiro‐Silva M, Abraldes JG, Iwakiri Y, Haq O, Groszmann RJ. Decreased intrahepatic response to α1‐adrenergic agonists in lipopolysaccharide‐treated rats is located in the sinusoidal area and depends on Kupffer cell function. Journal Of Gastroenterology And Hepatology 2007, 22: 893-900. PMID: 17498219, DOI: 10.1111/j.1440-1746.2007.04922.x.Peer-Reviewed Original ResearchConceptsLipopolysaccharide-treated ratsKupffer cell functionVascular responsesAdrenergic agonistsKupffer cellsNormal liverSinusoidal areaNitric oxide synthase inhibitorCell functionOxide synthase inhibitorRole of KupfferVascular tone controlNitric oxide overproductionKrebs-Henseleit solutionNitric oxide productionΑ1-adrenergic agonistDose-response curveIntrahepatic responseMicrovascular abnormalitiesSecond doseEndotoxemic ratsLiver perfusionSynthase inhibitorMethoxamineGadolinium chloride
2003
Mesenteric vasoconstriction triggers nitric oxide overproduction in the superior mesenteric artery of portal hypertensive rats
Tsai MH, Iwakiri Y, Cadelina G, Sessa WC, Groszmann RJ. Mesenteric vasoconstriction triggers nitric oxide overproduction in the superior mesenteric artery of portal hypertensive rats. Gastroenterology 2003, 125: 1452-1461. PMID: 14598261, DOI: 10.1016/j.gastro.2003.07.014.Peer-Reviewed Original ResearchConceptsPartial portal vein ligationSuperior mesenteric arterySMA vascular resistancePortal hypertensive ratsRAL ratsMesenteric vasoconstrictionPortal pressureVascular resistanceArterial pressureHypertensive ratsMesenteric arteryNitric oxide synthase activityNitric oxide synthase enzyme activitySMA blood flowMean arterial pressurePerfusion pressure changesPortal vein ligationENOS protein expressionSham-operated ratsOxide synthase activityMonomethyl-L-arginineNitric oxide overproductionEffects of vasoconstrictionRenal artery ligationENOS catalytic activity