Increased neuronal nitric oxide synthase interaction with soluble guanylate cyclase contributes to the splanchnic arterial vasodilation in portal hypertensive rats
Kwon SY, Groszmann RJ, Iwakiri Y. Increased neuronal nitric oxide synthase interaction with soluble guanylate cyclase contributes to the splanchnic arterial vasodilation in portal hypertensive rats. Hepatology Research 2007, 37: 58-67. PMID: 17300699, DOI: 10.1111/j.1872-034x.2007.00005.x.Peer-Reviewed Original ResearchNeuronal nitric oxide synthaseSplanchnic arterial vasodilationPortal hypertensive ratsPartial portal vein ligationSoluble guanylate cyclaseArterial vasodilationHypertensive ratsSmooth muscle layerContractile responseNNOS proteinNNOS inhibitorMuscle layerRole of nNOSSuperior mesenteric arterial bedNNOS-specific inhibitorPortal hypertensive groupPortal hypertensive stateMesenteric arterial bedPortal vein ligationSham-operated groupNitric oxide synthaseActivation of sGCNitric oxide releaseHypertensive groupPortal hypertension