Mesenteric vasoconstriction triggers nitric oxide overproduction in the superior mesenteric artery of portal hypertensive rats
Tsai MH, Iwakiri Y, Cadelina G, Sessa WC, Groszmann RJ. Mesenteric vasoconstriction triggers nitric oxide overproduction in the superior mesenteric artery of portal hypertensive rats. Gastroenterology 2003, 125: 1452-1461. PMID: 14598261, DOI: 10.1016/j.gastro.2003.07.014.Peer-Reviewed Original ResearchConceptsPartial portal vein ligationSuperior mesenteric arterySMA vascular resistancePortal hypertensive ratsRAL ratsMesenteric vasoconstrictionPortal pressureVascular resistanceArterial pressureHypertensive ratsMesenteric arteryNitric oxide synthase activityNitric oxide synthase enzyme activitySMA blood flowMean arterial pressurePerfusion pressure changesPortal vein ligationENOS protein expressionSham-operated ratsOxide synthase activityMonomethyl-L-arginineNitric oxide overproductionEffects of vasoconstrictionRenal artery ligationENOS catalytic activityMesenteric vasoconstriction is responsible for the initial eNOS upregulation in the superior mesenteric artery of portal hypertensive rats
Tsai M, Iwakiri Y, Cadelina G, Sessa W, Groszmann R. Mesenteric vasoconstriction is responsible for the initial eNOS upregulation in the superior mesenteric artery of portal hypertensive rats. Hepatology 2003, 38: 176-177. DOI: 10.1016/s0270-9139(03)80088-5.Peer-Reviewed Original Research