A liver-specific nitric oxide donor improves the intra-hepatic vascular response to both portal blood flow increase and methoxamine in cirrhotic rats
Loureiro-Silva MR, Cadelina GW, Iwakiri Y, Groszmann RJ. A liver-specific nitric oxide donor improves the intra-hepatic vascular response to both portal blood flow increase and methoxamine in cirrhotic rats. Journal Of Hepatology 2003, 39: 940-946. PMID: 14642609, DOI: 10.1016/j.jhep.2003.09.018.Peer-Reviewed Original ResearchConceptsBlood flow increasesCirrhotic ratsPortal pressureUrsodeoxycholic acidLiver perfusionFlow/pressure curvesNO donorAscitic cirrhotic ratsBlood volume expansionBasal heart rateSitu liver perfusionNitric oxide productionNitric oxide donorDose/response curveBlood flow measurementsPortal hypertensionHemodynamic effectsArterial pressureFlow increasesVascular responsesControl ratsBlood infusionBACKGROUND/Heart rateOxide donor