2019
O-GlcNAc transferase suppresses necroptosis and liver fibrosis
Zhang B, Li MD, Yin R, Liu Y, Yang Y, Mitchell-Richards KA, Nam JH, Li R, Wang L, Iwakiri Y, Chung D, Robert ME, Ehrlich BE, Bennett AM, Yu J, Nathanson MH, Yang X. O-GlcNAc transferase suppresses necroptosis and liver fibrosis. JCI Insight 2019, 4: e127709. PMID: 31672932, PMCID: PMC6948774, DOI: 10.1172/jci.insight.127709.Peer-Reviewed Original ResearchConceptsReceptor-interacting protein kinase 3Liver fibrosisLiver diseaseHepatocyte necroptosisEthanol-induced liver injuryAlcoholic liver cirrhosisChronic liver diseaseMultiple liver diseasesWeeks of ageProtein expression levelsPortal inflammationLiver cirrhosisLiver injuryBallooning degenerationElevated protein expression levelsSpontaneous genetic modelFibrosisKey suppressorKey mediatorMiceProtein kinase 3CirrhosisExpression levelsGlcNAc levelsMixed lineage kinase
2011
Pigment Epithelium-Derived Factor Regulates Early Pancreatic Fibrotic Responses and Suppresses the Profibrotic Cytokine Thrombospondin-1
Schmitz JC, Protiva P, Gattu AK, Utsumi T, Iwakiri Y, Neto AG, Quinn M, Cornwell ML, Fitchev P, Lugea A, Crawford SE, Chung C. Pigment Epithelium-Derived Factor Regulates Early Pancreatic Fibrotic Responses and Suppresses the Profibrotic Cytokine Thrombospondin-1. American Journal Of Pathology 2011, 179: 2990-2999. PMID: 21964188, PMCID: PMC3260804, DOI: 10.1016/j.ajpath.2011.08.009.Peer-Reviewed Original ResearchConceptsPigment epithelium-derived factorWild-type miceLoss of PEDFPEDF expressionQuantitative real-time PCRFibrotic responseNormal extracellular matrixWild-type animalsReal-time PCRSmooth muscle actin stainingExtracellular matrixIntragastric feeding modelMice fed ethanolPancreatitis responsesEarly fibrotic responseEpithelium-derived factorMuscle actin stainingSirius red stainingExpression levelsThrombospondin-1Actin stainingFibrogenic markersMore fibrosisPEDF overexpressionEthanol diet
2010
The type III inositol 1,4,5-trisphosphate receptor is associated with aggressiveness of colorectal carcinoma
Shibao K, Fiedler MJ, Nagata J, Minagawa N, Hirata K, Nakayama Y, Iwakiri Y, Nathanson MH, Yamaguchi K. The type III inositol 1,4,5-trisphosphate receptor is associated with aggressiveness of colorectal carcinoma. Cell Calcium 2010, 48: 315-323. PMID: 21075448, PMCID: PMC3572849, DOI: 10.1016/j.ceca.2010.09.005.Peer-Reviewed Original ResearchConceptsTrisphosphate receptorCaco-2 colon cancer cellsGain of expressionColorectal cancerColorectal carcinomaColon cancer cellsColon cancerType IIICellular functionsInhibition of apoptosisType III inositolLymph node metastasisDepth of invasionNormal colorectal mucosaShRNA knockdownMargin of tumorDevelopment of diseaseExpression levelsLiver metastasesCell proliferationNode metastasisTNM stageApoptosisColorectal mucosaIsoforms