Covid‐19 and Liver Injury: Role of Inflammatory Endotheliopathy, Platelet Dysfunction, and Thrombosis
McConnell MJ, Kondo R, Kawaguchi N, Iwakiri Y. Covid‐19 and Liver Injury: Role of Inflammatory Endotheliopathy, Platelet Dysfunction, and Thrombosis. Hepatology Communications 2022, 6: 255-269. PMID: 34658172, PMCID: PMC8652692, DOI: 10.1002/hep4.1843.Peer-Reviewed Original ResearchConceptsLiver injurySARS-CoV-2Severe acute respiratory syndrome coronavirus 2Coronavirus disease 2019 (COVID-19) symptomsAcute respiratory syndrome coronavirus 2Alcohol-related liver diseaseSARS-CoV-2 infectionRespiratory syndrome coronavirus 2Chronic liver failureLiver-related complicationsDirect viral infectionElevated aspartate aminotransferaseSyndrome coronavirus 2COVID-19Pathophysiologic explanationLiver failureLiver diseasePlatelet dysfunctionVascular inflammationInflammatory environmentHepatic effectsAlanine aminotransferaseViral infectionAspartate aminotransferaseHepatic fociAlcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcohol-related liver disease
Yang Y, Sangwung P, Kondo R, Jung Y, McConnell MJ, Jeong J, Utsumi T, Sessa WC, Iwakiri Y. Alcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcohol-related liver disease. Journal Of Hepatology 2021, 75: 377-386. PMID: 33675874, PMCID: PMC8292196, DOI: 10.1016/j.jhep.2021.02.028.Peer-Reviewed Original ResearchConceptsEndothelial nitric oxide synthaseAlcohol-induced liver injuryLiver sinusoidal endothelial cellsAlcohol-related liver diseaseLiver injuryLSEC dysfunctionHsp90 acetylationNO productionHistone deacetylase 6Liver diseaseTherapeutic strategiesHeat shock protein 90 (Hsp90) acetylationLiver sinusoidal endothelial dysfunctionSinusoidal endothelial cell dysfunctionMouse liver sinusoidal endothelial cellsEndothelial cell dysfunctionNitric oxide synthaseEthanol-fed miceSinusoidal endothelial dysfunctionPotential therapeutic approachPotential therapeutic strategyNitric oxide productionNew therapeutic strategiesSinusoidal endothelial cellsAcetylation of Hsp90