Featured Publications
Proteotype coevolution and quantitative diversity across 11 mammalian species
Ba Q, Hei Y, Dighe A, Li W, Maziarz J, Pak I, Wang S, Wagner GP, Liu Y. Proteotype coevolution and quantitative diversity across 11 mammalian species. Science Advances 2022, 8: eabn0756. PMID: 36083897, PMCID: PMC9462687, DOI: 10.1126/sciadv.abn0756.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological EvolutionGene Expression ProfilingMammalsProteomeProteomicsTranscriptomeConceptsMammalian speciesRNA metabolic processesCommon mammalian speciesUbiquitin-proteasome systemEvolutionary profilingMammalian lineagesProteomic methodsProtein degradationProtein abundanceGene expressionProtein expression levelsHigh interspeciesMetabolic processesCovariation analysisFunctional roleNucleotide levelExpression levelsQuantitative diversityCoevolutionMammalsSpeciesRemarkable variationExpressionTranscriptomeBiological variability
2021
Data-independent acquisition-based proteome and phosphoproteome profiling across six melanoma cell lines reveals determinants of proteotypes
Gao E, Li W, Wu C, Shao W, Di Y, Liu Y. Data-independent acquisition-based proteome and phosphoproteome profiling across six melanoma cell lines reveals determinants of proteotypes. Molecular Omics 2021, 17: 413-425. PMID: 33728422, PMCID: PMC8205956, DOI: 10.1039/d0mo00188k.Peer-Reviewed Original Research
2014
Glycoproteomic Analysis of Prostate Cancer Tissues by SWATH Mass Spectrometry Discovers N-acylethanolamine Acid Amidase and Protein Tyrosine Kinase 7 as Signatures for Tumor Aggressiveness*
Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R. Glycoproteomic Analysis of Prostate Cancer Tissues by SWATH Mass Spectrometry Discovers N-acylethanolamine Acid Amidase and Protein Tyrosine Kinase 7 as Signatures for Tumor Aggressiveness*. Molecular & Cellular Proteomics 2014, 13: 1753-1768. PMID: 24741114, PMCID: PMC4083113, DOI: 10.1074/mcp.m114.038273.Peer-Reviewed Original ResearchConceptsN-acylethanolamine acid amidaseProtein tyrosine kinase 7Non-aggressive prostate cancerTyrosine kinase 7Prostate cancerKinase 7N-glycositesDiverse biological processesPotential tissue biomarkersAggressive prostate cancerPCa tumor tissuesSWATH mass spectrometryTissue microarray analysisProstate cancer tissuesUrgent clinical needIdentification of biomarkersHuman proteomePCa aggressivenessMicroarray analysisBiological processesPCa casesTissue biomarkersTumor aggressivenessNormal prostateCancer tissues
2010
Proteomic mining in the dysplastic liver of WHV/c‐myc mice – insights and indicators for early hepatocarcinogenesis
Liu Y, Li C, Xing Z, Yuan X, Wu Y, Xu M, Tu K, Li Q, Wu C, Zhao M, Zeng R. Proteomic mining in the dysplastic liver of WHV/c‐myc mice – insights and indicators for early hepatocarcinogenesis. The FEBS Journal 2010, 277: 4039-4053. PMID: 20807235, DOI: 10.1111/j.1742-4658.2010.07795.x.Peer-Reviewed Original ResearchConceptsHepatocellular carcinomaMouse modelFK506-binding protein 4C-myc miceTransgenic mouse modelEarly HCC diagnosisAsymptomatic processC-myc-induced hepatocarcinogenesisDysplastic liversFerritin heavy chainHCC diagnosisTissue microarrayImmunohistochemical analysisStage IIITumor onsetPutative biomarkersSerum samplesWestern blottingEarly detectionControl casesEarly hepatocarcinogenesisProtein 4Cancer initiationProtein expression profilesDysplastic stage