On the Dependency of Cellular Protein Levels on mRNA Abundance
Liu Y, Beyer A, Aebersold R. On the Dependency of Cellular Protein Levels on mRNA Abundance. Cell 2016, 165: 535-550. PMID: 27104977, DOI: 10.1016/j.cell.2016.03.014.Peer-Reviewed Original ResearchConceptsProtein levelsGene expression regulationCellular protein levelsLong‐term state changeGenotype-phenotype relationshipsExpression regulationMRNA fluctuationsProtein biosynthesisGenomic informationProteomic profilingTranscript levelsGene expressionBiological processesMRNA abundanceLife science researchMRNA levelsShort-term adaptationComplete understandingProtein concentrationBiosynthesisCentral importanceLocal availabilityTranscriptsTemporal variationProteinThe interdependence of transcript and protein abundance: new data–new complexities
Liu Y, Aebersold R. The interdependence of transcript and protein abundance: new data–new complexities. Molecular Systems Biology 2016, 12: msb156720. PMID: 26792872, PMCID: PMC4731012, DOI: 10.15252/msb.20156720.Peer-Reviewed Original ResearchProtein abundanceGene expression controlER stress responseExpression controlTranslational regulationEndoplasmic reticulum stressMammalian cellsTranscriptomic changesStress responseReticulum stressProtein levelsTranscriptsAbundanceCellsRelative contributionRecent reportsRegulationRecent workChallenging questions