Featured Publications
Multi-omic measurements of heterogeneity in HeLa cells across laboratories
Liu Y, Mi Y, Mueller T, Kreibich S, Williams EG, Van Drogen A, Borel C, Frank M, Germain PL, Bludau I, Mehnert M, Seifert M, Emmenlauer M, Sorg I, Bezrukov F, Bena FS, Zhou H, Dehio C, Testa G, Saez-Rodriguez J, Antonarakis SE, Hardt WD, Aebersold R. Multi-omic measurements of heterogeneity in HeLa cells across laboratories. Nature Biotechnology 2019, 37: 314-322. PMID: 30778230, DOI: 10.1038/s41587-019-0037-y.Peer-Reviewed Original ResearchConceptsCell linesGenome-wide copy numberMulti-omic measurementsHuman cultured cellsProtein turnover ratesPhenotypic responsesGenomic variabilityDifferent cell linesHeLa variantsSpecific cell linesCopy numberHeLa cellsCultured cellsHeLa cell linePhenotypic variabilityProgressive divergenceTurnover rateCellsBiological variationTechnical variationUniform conditionsTranscriptomeProteomeSuccessive passagesLines
2017
Proteotyping Gene Dosage Effects in Genetic Diseases
Liu Y, Aebersold R. Proteotyping Gene Dosage Effects in Genetic Diseases. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.926.3.Peer-Reviewed Original ResearchGene dosage imbalanceCopy number variationsProtein degradationDosage imbalanceGenetic diseasesSubstantial post-transcriptional regulationHeteromeric protein complexesDivergent expression levelsPost-transcriptional regulationCorresponding protein abundanceDNA copy number variationsComponents of pathwaysTurnover analysisPatient-derived induced pluripotent stem cellsInduced pluripotent stem cellsSWATH mass spectrometryPluripotent stem cellsGene dosage effectProtein turnover ratesPluripotent stateTranscript profilingSILAC experimentsProtein complexesTranslational regulationRNA-seq