2018
Systems pharmacology using mass spectrometry identifies critical response nodes in prostate cancer
Ebhardt HA, Root A, Liu Y, Gauthier NP, Sander C, Aebersold R. Systems pharmacology using mass spectrometry identifies critical response nodes in prostate cancer. Npj Systems Biology And Applications 2018, 4: 26. PMID: 29977602, PMCID: PMC6026592, DOI: 10.1038/s41540-018-0064-1.Peer-Reviewed Original ResearchProstate carcinomaCombination therapyPCa cellsMTOR signal transduction pathwayDrug combinationsPCa disease progressionPI3K-AktAndrogen receptor statusUseful early markerMolecular responseSystems pharmacology approachPotential early indicatorReceptor statusDisease progressionSurgical specimensPCa treatmentProstate cancerSignal transduction pathwaysQuestion of efficacySingle drugDrug effectsResponse markersEarly markerPotential resistance pathwaysPharmacology approach
2014
Glycoproteomic Analysis of Prostate Cancer Tissues by SWATH Mass Spectrometry Discovers N-acylethanolamine Acid Amidase and Protein Tyrosine Kinase 7 as Signatures for Tumor Aggressiveness*
Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R. Glycoproteomic Analysis of Prostate Cancer Tissues by SWATH Mass Spectrometry Discovers N-acylethanolamine Acid Amidase and Protein Tyrosine Kinase 7 as Signatures for Tumor Aggressiveness*. Molecular & Cellular Proteomics 2014, 13: 1753-1768. PMID: 24741114, PMCID: PMC4083113, DOI: 10.1074/mcp.m114.038273.Peer-Reviewed Original ResearchConceptsN-acylethanolamine acid amidaseProtein tyrosine kinase 7Non-aggressive prostate cancerTyrosine kinase 7Prostate cancerKinase 7N-glycositesDiverse biological processesPotential tissue biomarkersAggressive prostate cancerPCa tumor tissuesSWATH mass spectrometryTissue microarray analysisProstate cancer tissuesUrgent clinical needIdentification of biomarkersHuman proteomePCa aggressivenessMicroarray analysisBiological processesPCa casesTissue biomarkersTumor aggressivenessNormal prostateCancer tissues