Evolution of higher mesenchymal CD44 expression in the human lineage
Ma X, Dighe A, Maziarz J, Neumann E, Erkenbrack E, Hei YY, Liu Y, Suhail Y, Kshitiz, Pak I, Levchenko A, Wagner GP. Evolution of higher mesenchymal CD44 expression in the human lineage. Evolution Medicine And Public Health 2022, 10: 447-462. PMID: 36148042, PMCID: PMC9487634, DOI: 10.1093/emph/eoac036.Peer-Reviewed Original ResearchCell type-specific factorsType-specific factorsEndometrial stromal fibroblastsHuman lineageCell type-specific functionsCell typesExtracellular matrix receptorsExpression increasesGene expression increasesReporter gene experimentsEvolutionary changePositive selectionFunction of CD44Regulatory elementsMatrix receptorsRegulatory mechanismsGene experimentsCancer progressionInvasibilityCD44 expressionFetal-maternal interactionIsoform expressionLineagesExpressionStromal fibroblasts