2018
Systems pharmacology using mass spectrometry identifies critical response nodes in prostate cancer
Ebhardt HA, Root A, Liu Y, Gauthier NP, Sander C, Aebersold R. Systems pharmacology using mass spectrometry identifies critical response nodes in prostate cancer. Npj Systems Biology And Applications 2018, 4: 26. PMID: 29977602, PMCID: PMC6026592, DOI: 10.1038/s41540-018-0064-1.Peer-Reviewed Original ResearchProstate carcinomaCombination therapyPCa cellsMTOR signal transduction pathwayDrug combinationsPCa disease progressionPI3K-AktAndrogen receptor statusUseful early markerMolecular responseSystems pharmacology approachPotential early indicatorReceptor statusDisease progressionSurgical specimensPCa treatmentProstate cancerSignal transduction pathwaysQuestion of efficacySingle drugDrug effectsResponse markersEarly markerPotential resistance pathwaysPharmacology approach
2016
Deep Phosphoproteomic Measurements Pinpointing Drug Induced Protective Mechanisms in Neuronal Cells
Yu C, Gao J, Zhou Y, Chen X, Xiao R, Zheng J, Liu Y, Zhou H. Deep Phosphoproteomic Measurements Pinpointing Drug Induced Protective Mechanisms in Neuronal Cells. Frontiers In Physiology 2016, 7: 635. PMID: 28066266, PMCID: PMC5179568, DOI: 10.3389/fphys.2016.00635.Peer-Reviewed Original ResearchAlzheimer's diseaseNeuro-2a cellsTau protein phosphorylationIrreversible neurological disordersDrug effectsNeurological disordersNeuronal cellsOlder populationClass IProtective mechanismPhosphorylation levelsNeuron systemDrug candidatesOxidative damageDiseaseMolecular mechanismsCellsInflammationQuantitative phosphoproteomeSILAC labelingPhosphoproteomic approachPhosphorylation changesNOS1PhosphorylationMice