2021
Effect of exercise on peritoneal microenvironment and progression of ovarian cancer.
Morrisson M, Bi F, Yang K, Cady S, Hartwich T, Cerchia A, Li Z, Kim J, Irwin M, Yang-Hartwich Y. Effect of exercise on peritoneal microenvironment and progression of ovarian cancer. American Journal Of Cancer Research 2021, 11: 5045-5062. PMID: 34765311, PMCID: PMC8569339.Peer-Reviewed Original ResearchEffects of exerciseOvarian cancerPeritoneal microenvironmentChemotherapy outcomesPatients' health-related qualityBlood urea nitrogen levelsMouse ovarian cancer modelIncidence of neutropeniaIntraperitoneal fat tissueProduction of CCL2Role of CCL2Health-related qualityDeadliest gynecological malignancyMetastatic ovarian cancerExercise-induced changesUrea nitrogen levelsOvarian cancer modelOvarian carcinoma progressionPotential beneficial effectsCancer cell viabilityPeritoneal colonizationCo-culture modelChronic exerciseClinical outcomesGynecological malignancies
2020
Ovarian BDNF promotes survival, migration, and attachment of tumor precursors originated from p53 mutant fallopian tube epithelial cells
Kang M, Chong KY, Hartwich TMP, Bi F, Witham AK, Patrick D, Morrisson MJ, Cady SL, Cerchia AP, Kelk D, Liu Y, Nucci J, Madarikan O, Ueno D, Shuch BM, Yang-Hartwich Y. Ovarian BDNF promotes survival, migration, and attachment of tumor precursors originated from p53 mutant fallopian tube epithelial cells. Oncogenesis 2020, 9: 55. PMID: 32471985, PMCID: PMC7260207, DOI: 10.1038/s41389-020-0243-y.Peer-Reviewed Original ResearchHigh-grade serous ovarian carcinomaBrain-derived neurotrophic factorFallopian tube epitheliumFTE cellsTumor precursorsPathophysiological processesTropomyosin receptor kinase BFallopian tube epithelial cellsBDNF/TrkBReceptor kinase BLethal gynecological malignancyGenetic alterationsSerous ovarian carcinomaFunction mutationsCommon TP53Gynecological malignanciesNeurotrophic factorFallopian tubeOvarian carcinomaRisk factorsFollicular fluidMutant p53 proteinVivo modelTP53 lossEpithelial cells