Featured Publications
Pathobionts from chemically disrupted gut microbiota induce insulin-dependent diabetes in mice
Yang X, Wang Z, Niu J, Zhai R, Xue X, Wu G, Fang Y, Meng G, Yuan H, Zhao L, Zhang C. Pathobionts from chemically disrupted gut microbiota induce insulin-dependent diabetes in mice. Microbiome 2023, 11: 62. PMID: 36978130, PMCID: PMC10052834, DOI: 10.1186/s40168-023-01507-z.Peer-Reviewed Original ResearchConceptsInsulin-dependent diabetesBeta-cell destructionGut microbiotaGut microbiomeDextran sulfate sodium treatmentAutoimmune type 1 diabetesCell destructionIDD developmentDysbiotic gut microbiotaGerm-free micePotential human relevanceType 1 diabetesNormal gut microbiomeGut pathobiontPancreatic inflammationC57BL/6 miceLocal inflammationNormal dietWildtype miceAnimal modelsDiabetesSodium treatmentPathobiontsPancreasHuman relevanceTlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis
Wang P, Yang X, Zhang L, Sha S, Huang J, Peng J, Gu J, Pearson J, Hu Y, Zhao H, Wong F, Wang Q, Wen L. Tlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis. Nature Communications 2024, 15: 4232. PMID: 38762479, PMCID: PMC11102548, DOI: 10.1038/s41467-024-48611-8.Peer-Reviewed Original ResearchConceptsToll-like receptor 9Gut microbiotaGut microbial communityTransferred to germ-free miceB cellsGerm-free miceTLR9 deficiencyKO miceGene sequencesGerminal center B cellsMicrobial communitiesMarginal zone B cellsGut dysbiosisFollicular helper cellsSelf-DNAMetabolic homeostasisAssociated with increased frequencyPro-inflammatory stateFat tissue inflammationGutHigh-fat dietMicrobiotaHelper cellsT cellsControl mice
2022
Chronic intermittent hypoxia induces gut microbial dysbiosis and infers metabolic dysfunction in mice
Zhang Y, Luo H, Niu Y, Yang X, Li Z, Wang K, Bi H, Pang X. Chronic intermittent hypoxia induces gut microbial dysbiosis and infers metabolic dysfunction in mice. Sleep Medicine 2022, 91: 84-92. PMID: 35286865, DOI: 10.1016/j.sleep.2022.02.003.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaCo-abundance groupsChronic intermittent hypoxiaIntermittent hypoxiaSystemic inflammationGut microbiotaGut microbiomeElevated systemic inflammationAdverse metabolic outcomesGut microbial dysbiosisMale C57BL/6 micePrevalent sleep disorderFatty acid metabolismIH miceIH exposureMetabolic riskSleep apneaC57BL/6 miceMicrobial dysbiosisComposition of microbiotaMetabolic outcomesIntestinal microbial communityMetabolism disordersMetabolic dysfunctionSleep disorders
2021
Ketogenic Diets Induced Glucose Intolerance and Lipid Accumulation in Mice with Alterations in Gut Microbiota and Metabolites
Li Y, Yang X, Zhang J, Jiang T, Zhang Z, Wang Z, Gong M, Zhao L, Zhang C. Ketogenic Diets Induced Glucose Intolerance and Lipid Accumulation in Mice with Alterations in Gut Microbiota and Metabolites. MBio 2021, 12: 10.1128/mbio.03601-20. PMID: 33785628, PMCID: PMC8092315, DOI: 10.1128/mbio.03601-20.Peer-Reviewed Original ResearchConceptsKetogenic dietGut microbiotaProportion of fatLipid metabolismGlucose intoleranceInsulin resistanceFat accumulationMouse trialsNeurodegenerative diseasesLipid accumulationMore fat accumulationInduced glucose intoleranceLipid metabolism disordersAffected lipid metabolismMetabolism disordersMetabolic disordersGlucose homeostasisGlucose metabolismSource of fatHuman studiesHigh fatTreatment of diseasesMiceBeneficial effectsWeight lossThe effect of calorie intake, fasting, and dietary composition on metabolic health and gut microbiota in mice
Zhang Z, Chen X, Loh Y, Yang X, Zhang C. The effect of calorie intake, fasting, and dietary composition on metabolic health and gut microbiota in mice. BMC Biology 2021, 19: 51. PMID: 33740961, PMCID: PMC7977615, DOI: 10.1186/s12915-021-00987-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimal FeedAnimalsDiet, High-FatEatingFastingGastrointestinal MicrobiomeGlucoseLipid MetabolismMaleMiceMice, Inbred C57BLRandom AllocationConceptsHigh-fat dietAd libitum groupMetabolic healthGut microbiotaIntermittent fastingNormal chow miceTotal energy intakeGut microbiota modulationDietary structureIF regimenMetabolic ameliorationNormal chowCR regimenMicrobiota modulationFood intakeDietary regimensCalorie intakeCR groupCR miceRegimenControl groupEnergy intakeGut microbial communityLipid metabolismFasting-refeeding cycle
2019
Strain-Specific Anti-inflammatory Properties of Two Akkermansia muciniphila Strains on Chronic Colitis in Mice
Zhai R, Xue X, Zhang L, Yang X, Zhao L, Zhang C. Strain-Specific Anti-inflammatory Properties of Two Akkermansia muciniphila Strains on Chronic Colitis in Mice. Frontiers In Cellular And Infection Microbiology 2019, 9: 239. PMID: 31334133, PMCID: PMC6624636, DOI: 10.3389/fcimb.2019.00239.Peer-Reviewed Original ResearchMeSH KeywordsAkkermansiaAnimalsAnti-Inflammatory AgentsCD4-Positive T-LymphocytesChronic DiseaseColitisColonCytokinesDextran SulfateDisease Models, AnimalDysbiosisFecesGastrointestinal MicrobiomeHT29 CellsHumansInterferon-gammaInterleukin-8MaleMiceMice, Inbred C57BLProbioticsRNA, Ribosomal, 16STumor Necrosis Factor-alphaVerrucomicrobiaWhole Genome SequencingConceptsInflammatory bowel diseaseAnti-inflammatory propertiesAnti-inflammatory effectsChronic colitisInflammation indexSpleen weightGut microbiotaBeneficial effectsSimilar anti-inflammatory propertiesColon histological scoresDifferentiation of TregsDextran sulfate sodiumPro-inflammatory cytokinesT cell populationsIL-8 productionColon of micePotential beneficial effectsShort-chain fatty acidsBowel diseaseIntestinal dysbiosisSulfate sodiumClinical parametersHT-29 cellsHistological scoresStrain-specific characteristics
2017
Flavonoid-enriched extract from Hippophae rhamnoides seed reduces high fat diet induced obesity, hypertriglyceridemia, and hepatic triglyceride accumulation in C57BL/6 mice
Yang X, Wang Q, Pang Z, Pan M, Zhang W. Flavonoid-enriched extract from Hippophae rhamnoides seed reduces high fat diet induced obesity, hypertriglyceridemia, and hepatic triglyceride accumulation in C57BL/6 mice. Pharmaceutical Biology 2017, 55: 1207-1214. PMID: 28248545, PMCID: PMC6130443, DOI: 10.1080/13880209.2016.1278454.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody WeightDiet, High-FatFlavonoidsHippophaeHypertriglyceridemiaLiverMaleMiceMice, Inbred C57BLObesityPlant ExtractsSeedsTriglyceridesConceptsHigh-fat dietAdipose tissueC57BL/6 miceFat dietFSH treatmentBody weightMRNA expressionAdipose tissue inflammationMolecular targetsLipid metabolism disordersObese mouse modelHepatic triglyceride accumulationEffect of FSHTNFα mRNA expressionPPARα mRNA expressionRegulation of PPARγBody weight gainPPARγ protein levelsPotential molecular targetsPPARα gene expressionFSH administrationMacrophage infiltrationTissue inflammationCholesterol levelsMetabolism disorders