Featured Publications
Tlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis
Wang P, Yang X, Zhang L, Sha S, Huang J, Peng J, Gu J, Pearson J, Hu Y, Zhao H, Wong F, Wang Q, Wen L. Tlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis. Nature Communications 2024, 15: 4232. PMID: 38762479, PMCID: PMC11102548, DOI: 10.1038/s41467-024-48611-8.Peer-Reviewed Original ResearchConceptsToll-like receptor 9Gut microbiotaGut microbial communityTransferred to germ-free miceB cellsGerm-free miceTLR9 deficiencyKO miceGene sequencesGerminal center B cellsMicrobial communitiesMarginal zone B cellsGut dysbiosisFollicular helper cellsSelf-DNAMetabolic homeostasisAssociated with increased frequencyPro-inflammatory stateFat tissue inflammationGutHigh-fat dietMicrobiotaHelper cellsT cellsControl mice
2021
The effect of calorie intake, fasting, and dietary composition on metabolic health and gut microbiota in mice
Zhang Z, Chen X, Loh Y, Yang X, Zhang C. The effect of calorie intake, fasting, and dietary composition on metabolic health and gut microbiota in mice. BMC Biology 2021, 19: 51. PMID: 33740961, PMCID: PMC7977615, DOI: 10.1186/s12915-021-00987-5.Peer-Reviewed Original ResearchConceptsHigh-fat dietAd libitum groupMetabolic healthGut microbiotaIntermittent fastingNormal chow miceTotal energy intakeGut microbiota modulationDietary structureIF regimenMetabolic ameliorationNormal chowCR regimenMicrobiota modulationFood intakeDietary regimensCalorie intakeCR groupCR miceRegimenControl groupEnergy intakeGut microbial communityLipid metabolismFasting-refeeding cycle