2024
Sequential covariate-adjusted randomization via hierarchically minimizing Mahalanobis distance and marginal imbalance
Yang H, Qin Y, Li Y, Hu F. Sequential covariate-adjusted randomization via hierarchically minimizing Mahalanobis distance and marginal imbalance. Biometrics 2024, 80: ujae047. PMID: 38801258, DOI: 10.1093/biomtc/ujae047.Peer-Reviewed Original ResearchConceptsCovariate balanceMarginal imbalanceAdaptive randomization methodsTreatment effect estimatesSequential allocation schemeModified Mahalanobis distanceRandomization methodSimulation studyCovariate imbalanceRandom processTheoretical guaranteesCovariatesImbalance measureEffect estimatesMahalanobis distanceCurrent patientSample size differencesMarginal balanceAllocation schemeConvergenceData analysisSuperior performance
2021
Testing for treatment effect in covariate-adaptive randomized trials with generalized linear models and omitted covariates
Li Y, Ma W, Qin Y, Hu F. Testing for treatment effect in covariate-adaptive randomized trials with generalized linear models and omitted covariates. Statistical Methods In Medical Research 2021, 30: 2148-2164. PMID: 33899607, DOI: 10.1177/09622802211008206.Peer-Reviewed Original ResearchConceptsCovariate-adaptive randomizationCovariate-adaptive randomization methodsCovariate-adaptive randomized trialsValidity of statistical inferenceInflated type I errorLinear modelType I errorGeneralized linear modelAsymptotic distributionProposed adjustment methodAsymptotic resultsInferential propertiesTest statisticsAnti-conservativeStatistical inferenceContinuous responseUnadjusted testsNull hypothesisTheoretical findingsTreatment effectsInvalid testsRandomization methodNumerical studyCovariatesAdjustment method