2013
Activation of Hypoxia‐Inducible Factor‐2 in Adipocytes Results in Pathological Cardiac Hypertrophy
Lin Q, Huang Y, Booth CJ, Haase VH, Johnson RS, Simon M, Giordano FJ, Yun Z. Activation of Hypoxia‐Inducible Factor‐2 in Adipocytes Results in Pathological Cardiac Hypertrophy. Journal Of The American Heart Association 2013, 2: e000548. PMID: 24326162, PMCID: PMC3886757, DOI: 10.1161/jaha.113.000548.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytesAnimalsBasic Helix-Loop-Helix Transcription FactorsCardiomegalyCytokinesDisease Models, AnimalGene Expression RegulationGenetic Predisposition to DiseaseHypoxia-Inducible Factor 1, alpha SubunitInflammation MediatorsMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMyocytes, CardiacPhenotypeSignal TransductionTime FactorsVon Hippel-Lindau Tumor Suppressor ProteinConceptsPathological cardiac hypertrophyCardiac hypertrophyHypoxia-inducible factor-2Hypoxia-signaling pathwayHypoxia-inducible factor (HIF) pathwayVon Hippel-Lindau (VHL) geneTranscription factorsUncharacterized mechanismAdipose tissueAdipocytes resultsHIF activationObesity-associated cardiomyopathyChemotactic protein-1Protein 1Activated T cellsDirect roleEssential roleCardiomyopathy-associated genesFactor 2Genetic deletionFactor pathwayUndefined mechanismDeletionNuclear factorGenes
2008
Chromogranin B Regulates Calcium Signaling, Nuclear Factor &kgr;B Activity, and Brain Natriuretic Peptide Production in Cardiomyocytes
Heidrich FM, Zhang K, Estrada M, Huang Y, Giordano FJ, Ehrlich BE. Chromogranin B Regulates Calcium Signaling, Nuclear Factor &kgr;B Activity, and Brain Natriuretic Peptide Production in Cardiomyocytes. Circulation Research 2008, 102: 1230-1238. PMID: 18420944, PMCID: PMC2952358, DOI: 10.1161/circresaha.107.166033.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAngiotensin IIAnimalsCalciumCalcium SignalingCardiomegalyCells, CulturedChromogranin BInositol 1,4,5-Trisphosphate ReceptorsMyocytes, CardiacNatriuretic Peptide, BrainNFATC Transcription FactorsNF-kappa BPromoter Regions, GeneticRatsTranscription, GeneticVasoconstrictor AgentsConceptsBrain natriuretic peptideAngiotensin IICardiac hypertrophyBNP productionChromogranin BNuclear factorNuclear factor-kappaB activityNatriuretic peptide productionActivated T cellsNuclear factor-kappaBLuciferase reporter assaysHeart failureNatriuretic peptideBasal secretionCardiovascular diseaseT cellsKappaB activityFactor-kappaBHypertrophyCGB expressionBNP promoterPotent inducerAdult cardiomyocytesOctapeptide hormoneCalcium signaling