2010
Cellular Endocytosis and Gene Delivery
Ziello J, Huang Y, Jovin I. Cellular Endocytosis and Gene Delivery. Molecular Medicine 2010, 16: 222-229. PMID: 20454523, PMCID: PMC2864810, DOI: 10.2119/molmed.2009.00101.Peer-Reviewed Original ResearchConceptsGene therapyNonviral vectorsClathrin-independent endocytic processVariety of vectorsUnderstanding of endocytosisClathrin-dependent endocytosisCurrent molecular medicineMechanism of endocytosisGene deliveryLipid raftsEndocytic processVector deliveryCellular traffickingCellular endocytosisEndocytosisMolecular medicineTraffickingTarget cellsCellsMetabolic diseasesTherapeutic potentialCaveolaeGenesDeliveryAdeno
2006
An engineered VEGF‐activating zinc finger protein transcription factor improves blood flow and limb salvage in advanced‐age mice
Yu J, Lei L, Liang Y, Hinh L, Hickey RP, Huang Y, Liu D, Yeh JL, Rebar E, Case C, Spratt K, Sessa WC, Giordano FJ. An engineered VEGF‐activating zinc finger protein transcription factor improves blood flow and limb salvage in advanced‐age mice. The FASEB Journal 2006, 20: 479-481. PMID: 16423874, DOI: 10.1096/fj.04-3670fje.Peer-Reviewed Original ResearchMeSH KeywordsAdenoviridaeAgingAmino Acid SequenceAnimalsBlood Flow VelocityFeasibility StudiesGene Expression RegulationGenes, SyntheticGenetic TherapyGenetic VectorsHindlimbIschemiaLaser-Doppler FlowmetryMiceMice, Inbred C57BLMolecular Sequence DataNeovascularization, PhysiologicProtein EngineeringRecombinant ProteinsRNA, MessengerStructure-Activity RelationshipTranscription FactorsVascular Endothelial Growth Factor AZinc FingersConceptsLimb salvageBlood flowHindlimb ischemiaC57/BL6 micePeripheral vascular diseaseVascular endothelial growth factorPotential clinical utilityEndothelial growth factorExpression of VEGFABL6 miceIschemic limbsVascular diseaseIschemic hindlimbMurine modelClinical utilityVessel countProtein transcription factorsGrowth factorProtein levelsSalvage