Loss of HIF-1α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis
Tang N, Wang L, Esko J, Giordano FJ, Huang Y, Gerber HP, Ferrara N, Johnson RS. Loss of HIF-1α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 2004, 6: 485-495. PMID: 15542432, DOI: 10.1016/j.ccr.2004.09.026.Peer-Reviewed Original ResearchAnimalsCell HypoxiaCell ProliferationCells, CulturedChemotaxisEndothelial CellsGene Expression RegulationHypoxia-Inducible Factor 1, alpha SubunitMiceNeoplasmsNeovascularization, PathologicTranscription FactorsVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2Wound Healing