Urocortin2 inhibits tumor growth via effects on vascularization and cell proliferation
Hao Z, Huang Y, Cleman J, Jovin IS, Vale WW, Bale TL, Giordano FJ. Urocortin2 inhibits tumor growth via effects on vascularization and cell proliferation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 3939-3944. PMID: 18308934, PMCID: PMC2268793, DOI: 10.1073/pnas.0712366105.Peer-Reviewed Original ResearchConceptsInhibits tumor growthTumor growthTumor vascularizationActivation of CRFR2Potential therapeutic roleTumor growth inhibitionTumor-suppressing effectsCRFR2 activationMeasurable tumorsTumor cell cyclingCell tumorsTherapeutic roleClinical malignancyUrocortin 2Peripheral tissuesCRFR2Ucn2Genetic deletionTissue vascularityDirect inhibitionVessel diameterCell proliferationVessel numberVascularizationTumors