2007
Reexpression of caveolin-1 in endothelium rescues the vascular, cardiac, and pulmonary defects in global caveolin-1 knockout mice
Murata T, Lin MI, Huang Y, Yu J, Bauer PM, Giordano FJ, Sessa WC. Reexpression of caveolin-1 in endothelium rescues the vascular, cardiac, and pulmonary defects in global caveolin-1 knockout mice. Journal Of Experimental Medicine 2007, 204: 2373-2382. PMID: 17893196, PMCID: PMC2118452, DOI: 10.1084/jem.20062340.Peer-Reviewed Original ResearchConceptsPulmonary hypertensionRC miceCaveolin-1Endothelial cellsCav-1 KO miceEpithelial cellsCav-1-deficient miceSmooth muscle contractilityEndothelial NO synthase activationNitric oxide productionBronchiolar epithelial cellsNO synthase activationSmooth muscle cellsClear physiological evidenceCaveolin-1 knockout miceLack of rescueCav-1 expressionPulmonary dysfunctionPrincipal structural componentPulmonary arteryPulmonary defectsKO miceMuscle contractilityMyocardial hypertrophyAlveolar hyperplasia
2004
Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis
Bauer PM, Yu J, Chen Y, Hickey R, Bernatchez PN, Looft-Wilson R, Huang Y, Giordano F, Stan RV, Sessa WC. Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 102: 204-209. PMID: 15615855, PMCID: PMC544041, DOI: 10.1073/pnas.0406092102.Peer-Reviewed Original ResearchConceptsEndothelial-specific expressionCav-1Function of caveolaeMitogen-activated protein kinaseCaveolin-1 geneAkt-Endothelial Nitric Oxide Synthase PathwayCaveolae biogenesisPhosphorylation of AktOrganelle numberProtein kinaseCav-1 expressionCaveolae numberEndothelial barrier functionSynthase pathwayEssential roleEndothelial nitric oxide synthase activationExogenous VEGFPhosphorylationCritical roleNitric oxide synthase activationAngiogenic responseSynthase activationTransgenic miceExpressionPathway