2007
Hypoxia-Inducible Factor (HIF)-1 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemia.
Ziello J, Jovin I, Huang Y. Hypoxia-Inducible Factor (HIF)-1 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemia. The Yale Journal Of Biology And Medicine 2007, 80: 51-60. PMID: 18160990, PMCID: PMC2140184.Peer-Reviewed Original ResearchConceptsHIF-1HIF-1 pathwayHypoxia-inducible factorDimeric protein complexProtein complexesCrucial physiological regulatorTranscription factorsTarget genesRegulatory pathwaysTranscriptional activityPrimary genesGenesPhysiological regulatorHomeostatic processesVessel proliferationLow oxygen concentrationsPathwayAnaerobic metabolismSmall moleculesCancerous cellsTherapeutic interventionsSpread of cancerProliferationTreatment of diseasesAngiogenic properties
2004
Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis
Bauer PM, Yu J, Chen Y, Hickey R, Bernatchez PN, Looft-Wilson R, Huang Y, Giordano F, Stan RV, Sessa WC. Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 102: 204-209. PMID: 15615855, PMCID: PMC544041, DOI: 10.1073/pnas.0406092102.Peer-Reviewed Original ResearchConceptsEndothelial-specific expressionCav-1Function of caveolaeMitogen-activated protein kinaseCaveolin-1 geneAkt-Endothelial Nitric Oxide Synthase PathwayCaveolae biogenesisPhosphorylation of AktOrganelle numberProtein kinaseCav-1 expressionCaveolae numberEndothelial barrier functionSynthase pathwayEssential roleEndothelial nitric oxide synthase activationExogenous VEGFPhosphorylationCritical roleNitric oxide synthase activationAngiogenic responseSynthase activationTransgenic miceExpressionPathway