2013
Activation of Hypoxia‐Inducible Factor‐2 in Adipocytes Results in Pathological Cardiac Hypertrophy
Lin Q, Huang Y, Booth CJ, Haase VH, Johnson RS, Simon M, Giordano FJ, Yun Z. Activation of Hypoxia‐Inducible Factor‐2 in Adipocytes Results in Pathological Cardiac Hypertrophy. Journal Of The American Heart Association 2013, 2: e000548. PMID: 24326162, PMCID: PMC3886757, DOI: 10.1161/jaha.113.000548.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytesAnimalsBasic Helix-Loop-Helix Transcription FactorsCardiomegalyCytokinesDisease Models, AnimalGene Expression RegulationGenetic Predisposition to DiseaseHypoxia-Inducible Factor 1, alpha SubunitInflammation MediatorsMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMyocytes, CardiacPhenotypeSignal TransductionTime FactorsVon Hippel-Lindau Tumor Suppressor ProteinConceptsPathological cardiac hypertrophyCardiac hypertrophyHypoxia-inducible factor-2Hypoxia-signaling pathwayHypoxia-inducible factor (HIF) pathwayVon Hippel-Lindau (VHL) geneTranscription factorsUncharacterized mechanismAdipose tissueAdipocytes resultsHIF activationObesity-associated cardiomyopathyChemotactic protein-1Protein 1Activated T cellsDirect roleEssential roleCardiomyopathy-associated genesFactor 2Genetic deletionFactor pathwayUndefined mechanismDeletionNuclear factorGenes
2004
Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis
Bauer PM, Yu J, Chen Y, Hickey R, Bernatchez PN, Looft-Wilson R, Huang Y, Giordano F, Stan RV, Sessa WC. Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 102: 204-209. PMID: 15615855, PMCID: PMC544041, DOI: 10.1073/pnas.0406092102.Peer-Reviewed Original ResearchConceptsEndothelial-specific expressionCav-1Function of caveolaeMitogen-activated protein kinaseCaveolin-1 geneAkt-Endothelial Nitric Oxide Synthase PathwayCaveolae biogenesisPhosphorylation of AktOrganelle numberProtein kinaseCav-1 expressionCaveolae numberEndothelial barrier functionSynthase pathwayEssential roleEndothelial nitric oxide synthase activationExogenous VEGFPhosphorylationCritical roleNitric oxide synthase activationAngiogenic responseSynthase activationTransgenic miceExpressionPathway