2013
The Effect of Differentiation Induction on FAK and Src Activity in Live HMSCs Visualized by FRET
Liao X, Lu S, Wu Y, Xu W, Zhuo Y, Peng Q, Li B, Zhang L, Wang Y. The Effect of Differentiation Induction on FAK and Src Activity in Live HMSCs Visualized by FRET. PLOS ONE 2013, 8: e72233. PMID: 24015220, PMCID: PMC3754985, DOI: 10.1371/journal.pone.0072233.Peer-Reviewed Original ResearchMeSH KeywordsCell DifferentiationCells, CulturedCSK Tyrosine-Protein KinaseEnzyme ActivationFeedback, PhysiologicalFluorescence Resonance Energy TransferFocal Adhesion Kinase 1HumansMesenchymal Stem CellsProto-Oncogene ProteinsProto-Oncogene Proteins p21(ras)Ras ProteinsSignal TransductionSrc-Family KinasesTissue EngineeringConceptsSrc activationCell differentiationStem cell differentiationInhibiting FAK activityStages of stem cell differentiationPlasma membrane of human mesenchymal stem cellsSrc biosensorFAK activationActivated FAKActivated SrcFate decisionsInduction reagentsFAKSrc signalingKinase activityPlasma membraneSrcRegulation mechanismLiving human mesenchymal stem cellsUp-regulatedHuman mesenchymal stem cellsDifferentiation inductionNeural inductionDifferentiationCells
2012
Visualization of Src and FAK Activity during the Differentiation Process from HMSCs to Osteoblasts
Liao X, Lu S, Zhuo Y, Winter C, Xu W, Wang Y. Visualization of Src and FAK Activity during the Differentiation Process from HMSCs to Osteoblasts. PLOS ONE 2012, 7: e42709. PMID: 22900044, PMCID: PMC3416797, DOI: 10.1371/journal.pone.0042709.Peer-Reviewed Original ResearchConceptsSrc activationFluorescence resonance energy transferFAK activationDifferentiation processActivation of FAKRegulates cellular adhesionSrc biosensorKinase FAKInduction of differentiationResonance energy transferFAKBiochemical signalsSrcCellular adhesionLiving cellsStem cellsOsteoblast differentiation processDifferentiationCellsBone cellsSrc/FAKInductionMesenchymal stem cellsActivityGenetics