2015
Label-Free Biosensor Imaging on Photonic Crystal Surfaces
Zhuo Y, Cunningham B. Label-Free Biosensor Imaging on Photonic Crystal Surfaces. Sensors 2015, 15: 21613-21635. PMID: 26343684, PMCID: PMC4610529, DOI: 10.3390/s150921613.Peer-Reviewed Original ResearchConceptsPhotonic crystal surfaceCrystal surfaceImaging detection instrumentMetal plasmonic nanoparticlesDielectric nanoparticlesPhotobleachable fluorescent dyesOptical scatteringDielectric permittivityNanostructure designSensing resolutionOperating principleSubstrate surfaceCytotoxic stainsOptical microscopyPlasmonic nanoparticlesBiomaterial interactionsMatrix surfaceBiomolecular layerDetection instrumentKinetic monitoringPhotonsLabel-freeNanoparticlesSurfaceNanoparticle contrast agents
2014
Single nanoparticle detection using photonic crystal enhanced microscopy
Zhuo Y, Hu H, Chen W, Lu M, Tian L, Yu H, Long K, Chow E, King W, Singamaneni S, Cunningham B. Single nanoparticle detection using photonic crystal enhanced microscopy. Analyst 2014, 139: 1007-1015. PMID: 24432353, DOI: 10.1039/c3an02295a.Peer-Reviewed Original ResearchConceptsPhotonic crystalsResonance wavelengthMetal nanoparticlesSingle-nanoparticle imagingExperimental demonstrationReflection efficiencySpatial resolutionWavelengthBiosensor surfaceTime-domain computer simulationsNanoparticle detectionIndividual nanoparticlesReflection propertiesNanoparticlesCrystalLocal reductionMetalSurface attachmentReflection magnitudeBiosensorLocal shiftsComputer simulationsMoleculesBiosensingProtein-protein Binding Detection with Nanoparticle Photonic Crystal Enhanced Microscopy (NP-PCEM)* *Research supported by National Science Foundation
Zhuo Y, Tian L, Chen W, Yu H, Singamaneni S, Cunningham B. Protein-protein Binding Detection with Nanoparticle Photonic Crystal Enhanced Microscopy (NP-PCEM)* *Research supported by National Science Foundation. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2014, 2014: 2069-2072. PMID: 25570391, DOI: 10.1109/embc.2014.6944023.Peer-Reviewed Original ResearchConceptsPhotonic crystalsLocalized surface plasmon resonance frequencyPC biosensorPhotonic crystal biosensorIndividual nanoparticlesSurface plasmon resonance frequencyPlasmon resonance frequencyResonance wavelengthExperimental demonstrationPresence of individual nanoparticlesBiosensing approachProtein-protein bindingBiosensorFunctionalized nanoparticlesNanoparticlesResonant frequencySurface adsorptionNanoparticle resolutionCrystalBinding detectionImaging approachResonanceFinite-differenceWavelength