2015
Label-Free Biosensor Imaging on Photonic Crystal Surfaces
Zhuo Y, Cunningham B. Label-Free Biosensor Imaging on Photonic Crystal Surfaces. Sensors 2015, 15: 21613-21635. PMID: 26343684, PMCID: PMC4610529, DOI: 10.3390/s150921613.Peer-Reviewed Original ResearchMeSH KeywordsBiocompatible MaterialsBiosensing TechniquesEquipment DesignNanoparticlesPhotonsProtein BindingConceptsPhotonic crystal surfaceCrystal surfaceImaging detection instrumentMetal plasmonic nanoparticlesDielectric nanoparticlesPhotobleachable fluorescent dyesOptical scatteringDielectric permittivityNanostructure designSensing resolutionOperating principleSubstrate surfaceCytotoxic stainsOptical microscopyPlasmonic nanoparticlesBiomaterial interactionsMatrix surfaceBiomolecular layerDetection instrumentKinetic monitoringPhotonsLabel-freeNanoparticlesSurfaceNanoparticle contrast agents
2014
Single nanoparticle detection using photonic crystal enhanced microscopy
Zhuo Y, Hu H, Chen W, Lu M, Tian L, Yu H, Long K, Chow E, King W, Singamaneni S, Cunningham B. Single nanoparticle detection using photonic crystal enhanced microscopy. Analyst 2014, 139: 1007-1015. PMID: 24432353, DOI: 10.1039/c3an02295a.Peer-Reviewed Original ResearchConceptsPhotonic crystalsResonance wavelengthMetal nanoparticlesSingle-nanoparticle imagingExperimental demonstrationReflection efficiencySpatial resolutionWavelengthBiosensor surfaceTime-domain computer simulationsNanoparticle detectionIndividual nanoparticlesReflection propertiesNanoparticlesCrystalLocal reductionMetalSurface attachmentReflection magnitudeBiosensorLocal shiftsComputer simulationsMoleculesBiosensing
2013
Photonic crystal enhanced microscopy for imaging of live cell adhesion
Chen W, Long K, Lu M, Chaudhery V, Yu H, Choi J, Polans J, Zhuo Y, Harley B, Cunningham B. Photonic crystal enhanced microscopy for imaging of live cell adhesion. Analyst 2013, 138: 5886-5894. PMID: 23971078, DOI: 10.1039/c3an01541f.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiosensing TechniquesCell AdhesionCells, CulturedChemotaxisCrystallizationMiceMicroscopy, ConfocalOptical PhenomenaStem CellsConceptsTime-resolved imagingPhotonic crystalsRelevant time-scalesTime-scalesDrug-induced apoptosisSubmicron resolutionSpatial resolutionMorphological signaturesStem cell differentiationCell-surface interactionsFilopodial extensionsPhotonsCell adhesionCell differentiationDynamic informationCell attachmentLiving cell adhesionMonitor cell behaviorCell behaviorBiological phenomenaResolutionApoptosisEvolutionChemotaxisLabel-free