2019
Photonic crystal slab biosensors fabricated with helium ion lithography (HIL)
Zhuo Y, Hu H, Wang Y, Marin T, Lu M. Photonic crystal slab biosensors fabricated with helium ion lithography (HIL). Sensors And Actuators A Physical 2019, 297: 111493. DOI: 10.1016/j.sna.2019.07.017.Peer-Reviewed Original ResearchHelium-ion lithographyPhotonic crystal slabCrystal slabIon lithographyFabricating photonic crystal slabsPhotonic crystal biosensorNano-hole patternsPhotonic bandgapDielectric nanostructuresFabricated nano-structuresLabel-free optical biosensorNanoimprint lithographyNanofabrication processHeliumRefractive indexNano-gratingsRefractometric sensorLithographyNano-structuresNano-patternsOptical biosensorsMaster moldFabrication approachSlabBandgap
2018
Quantitative analysis of focal adhesion dynamics using photonic resonator outcoupler microscopy (PROM)
Zhuo Y, Choi J, Marin T, Yu H, Harley B, Cunningham B. Quantitative analysis of focal adhesion dynamics using photonic resonator outcoupler microscopy (PROM). Light: Science & Applications 2018, 7: 9. PMID: 29963322, PMCID: PMC6020849, DOI: 10.1038/s41377-018-0001-5.Peer-Reviewed Original ResearchFocal adhesion dynamicsFocal adhesion areaFocal adhesion formationPhotonic crystal biosensorCell surface contactFocal adhesionsReflection peak intensityAdhesion dynamicsRegulate adhesionCell membrane componentsCell-surface interactionsLabel-free modalityEvanescent fieldMembrane componentsLabel-free approachMigration speedPeak intensityCluster dimensionCell interactionsQuantitative imagingBasement membraneAdhesion areaEpithelial stem cellsPhotonsCells
2016
Quantitative imaging of cell membrane-associated effective mass density using Photonic Crystal Enhanced Microscopy (PCEM)
Zhuo Y, Choi J, Marin T, Yu H, Harley B, Cunningham B. Quantitative imaging of cell membrane-associated effective mass density using Photonic Crystal Enhanced Microscopy (PCEM). Progress In Quantum Electronics 2016, 50: 1-18. PMID: 28649149, PMCID: PMC5479321, DOI: 10.1016/j.pquantelec.2016.10.001.Peer-Reviewed Original ResearchTight spatial confinementNarrow resonance peakEffective mass densityLabel-free live cell imagingAxial spatial resolutionPhotonic crystal biosensorPlasma membraneResonance peakMass densityEvanescent fieldSpatial confinementCell adhesionPhenotype of single cellsLight sourcesSpatial resolutionNon-coherent light sourceLive cell imagingComplex spatiotemporal informationCellular materialCellular processesQuantitative imagingMechanical propertiesCell surface interfaceMigration eventsMatrix material
2014
Protein-protein Binding Detection with Nanoparticle Photonic Crystal Enhanced Microscopy (NP-PCEM)* *Research supported by National Science Foundation
Zhuo Y, Tian L, Chen W, Yu H, Singamaneni S, Cunningham B. Protein-protein Binding Detection with Nanoparticle Photonic Crystal Enhanced Microscopy (NP-PCEM)* *Research supported by National Science Foundation. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2014, 2014: 2069-2072. PMID: 25570391, DOI: 10.1109/embc.2014.6944023.Peer-Reviewed Original ResearchConceptsPhotonic crystalsLocalized surface plasmon resonance frequencyPC biosensorPhotonic crystal biosensorIndividual nanoparticlesSurface plasmon resonance frequencyPlasmon resonance frequencyResonance wavelengthExperimental demonstrationPresence of individual nanoparticlesBiosensing approachProtein-protein bindingBiosensorFunctionalized nanoparticlesNanoparticlesResonant frequencySurface adsorptionNanoparticle resolutionCrystalBinding detectionImaging approachResonanceFinite-differenceWavelength