2015
Mediators of the Effect of Body Mass Index on Coronary Heart Disease
Lu Y, Hajifathalian K, Rimm EB, Ezzati M, Danaei G. Mediators of the Effect of Body Mass Index on Coronary Heart Disease. Epidemiology 2015, 26: 153-162. PMID: 25643095, DOI: 10.1097/ede.0000000000000234.Peer-Reviewed Original ResearchConceptsBody mass indexCoronary heart diseaseExcess relative riskHigh-sensitive C-reactive proteinHigher body mass indexC-reactive proteinBlood pressureRelative riskMass indexBlood glucoseHeart diseaseRisk factorsMetabolic risk factorsProspective cohort studyPrevalence of overweightMajor risk factorRandom-effects modelProthrombotic biomarkersCHD eventsCohort studyInflammatory biomarkersObese participantsMetabolic mediatorsMetabolic factorsMultiplicative scale
2013
Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1·8 million participants
Lu Y, Hajifathalian K, Ezzati M, Woodward M, Rimm E, Danaei G. Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1·8 million participants. The Lancet 2013, 383: 970-983. PMID: 24269108, PMCID: PMC3959199, DOI: 10.1016/s0140-6736(13)61836-x.Peer-Reviewed Original ResearchConceptsBody mass indexCoronary heart diseaseHigher body mass indexHazard ratioBlood pressureExcess riskHeart diseaseEffect of BMIImperial College Healthcare NHS TrustMetabolic risk factorsProspective cohort studyAverage blood pressureHigh blood pressureCardiovascular disease preventionUK Medical Research CouncilNational InstituteRandom-effects modelMedical Research CouncilBiomedical Research CentreCohort studyProspective cohortStroke eventsNormal weightPooled analysisUS National Institutes