2024
Association of marital/partner status with hospital readmission among young adults with acute myocardial infarction.
Zhu C, Dreyer R, Li F, Spatz E, Caraballo C, Mahajan S, Raparelli V, Leifheit E, Lu Y, Krumholz H, Spertus J, D'Onofrio G, Pilote L, Lichtman J. Association of marital/partner status with hospital readmission among young adults with acute myocardial infarction. PLOS ONE 2024, 19: e0287949. PMID: 38277368, PMCID: PMC10817183, DOI: 10.1371/journal.pone.0287949.Peer-Reviewed Original ResearchConceptsMarital/partner statusPsychosocial factorsAcute myocardial infarctionYoung adultsHospital dischargeYear of hospital dischargeYoung acute myocardial infarctionAssociated with 1.3-foldCohort of young adultsLong-term readmissionCox proportional hazards modelsStatus interactionSimilar-aged menMyocardial infarctionProportional hazards modelUnpartnered statusPatient interviewsPhysician panelCardiovascular healthHospital readmissionSocioeconomic factorsAMI survivorsSequential adjustmentCardiac readmissionMultiple imputation
2023
Uncovering heterogeneous cardiometabolic risk profiles in US adults: the role of social and behavioral determinants of health
Ding Q, Lu Y, Herrin J, Zhang T, Marrero D. Uncovering heterogeneous cardiometabolic risk profiles in US adults: the role of social and behavioral determinants of health. BMJ Open Diabetes Research & Care 2023, 11: e003558. PMID: 37699720, PMCID: PMC10503393, DOI: 10.1136/bmjdrc-2023-003558.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DrinkingCardiovascular DiseasesHumansMaleMiddle AgedNutrition SurveysPrediabetic StateRisk FactorsConceptsCardiometabolic risk profileMetabolic risk factorsRace/ethnicityUndiagnosed diabetesUS adultsRisk factorsHealthcare accessNutrition Examination Survey 1999Risk profilePre-diabetes riskPrior diabetes diagnosisExamination Survey 1999Insurance coverageShort sleep durationLower diet qualityEffective prevention strategiesLimited healthcare accessBehavioral determinantsNon-white adultsMiddle-aged adultsHealth insurance coverageLow health insurance coverageCardiometabolic riskDiabetes statusDiabetes riskSex Difference in Outcomes of Acute Myocardial Infarction in Young Patients
Sawano M, Lu Y, Caraballo C, Mahajan S, Dreyer R, Lichtman J, D'Onofrio G, Spatz E, Khera R, Onuma O, Murugiah K, Spertus J, Krumholz H. Sex Difference in Outcomes of Acute Myocardial Infarction in Young Patients. Journal Of The American College Of Cardiology 2023, 81: 1797-1806. PMID: 37137590, DOI: 10.1016/j.jacc.2023.03.383.Peer-Reviewed Original ResearchMeSH KeywordsFemaleHealth StatusHospitalizationHumansMaleMyocardial InfarctionRisk FactorsSex CharacteristicsSex FactorsConceptsAcute myocardial infarctionNoncardiac hospitalizationsSubdistribution HRYounger patientsMyocardial infarctionSex differencesYoung womenCause-specific hospitalizationsCause of hospitalizationWorse health statusSignificant sex disparityNoncardiovascular hospitalizationsVIRGO StudyIndex episodeAdverse outcomesIncidence rateHospitalizationHigh riskSex disparitiesHealth statusPatientsU.S. hospitalsWomenInfarctionOutcomesQuantifying Blood Pressure Visit-to-Visit Variability in the Real-World Setting: A Retrospective Cohort Study
Lu Y, Linderman G, Mahajan S, Liu Y, Huang C, Khera R, Mortazavi B, Spatz E, Krumholz H. Quantifying Blood Pressure Visit-to-Visit Variability in the Real-World Setting: A Retrospective Cohort Study. Circulation Cardiovascular Quality And Outcomes 2023, 16: e009258. PMID: 36883456, DOI: 10.1161/circoutcomes.122.009258.Peer-Reviewed Original ResearchConceptsRetrospective cohort studyBlood pressure valuesPatient characteristicsReal-world settingCohort studyPatient subgroupsYale New Haven Health SystemMean body mass indexSystolic blood pressure valuesBlood pressure visitHistory of hypertensionCoronary artery diseaseManagement of patientsMultivariable linear regression modelsBlood pressure readingsBody mass indexPatient-level measuresBlood pressure variationAbsolute standardized differencesNon-Hispanic whitesAntihypertensive medicationsReal-world practiceVisit variabilityArtery diseaseRegression modelsSex-Related Differences in Patient Characteristics, Risk Factors, and Symptomatology in Older Adults with Pulmonary Embolism: Findings from the SERIOUS-PE Study
Bikdeli B, Muriel A, Wang Y, Piazza G, Khairani C, Rosovsky R, Mehdipoor G, O'Donoghue M, Madridano O, Lopez-Saez J, Mellado M, Brasero A, Grandone E, Spagnolo P, Lu Y, Bertoletti L, López-Jiménez L, Núñez M, Blanco-Molina Á, Gerhard-Herman M, Goldhaber S, Bates S, Jimenez D, Krumholz H, Monreal M. Sex-Related Differences in Patient Characteristics, Risk Factors, and Symptomatology in Older Adults with Pulmonary Embolism: Findings from the SERIOUS-PE Study. Seminars In Thrombosis And Hemostasis 2023, 49: 725-735. PMID: 36868268, DOI: 10.1055/s-0043-1764231.Peer-Reviewed Original ResearchMeSH KeywordsAgedFemaleHumansMaleMedicareNeoplasmsPulmonary EmbolismRisk FactorsSex CharacteristicsUnited StatesConceptsOlder adultsClinical characteristicsRisk factorsElderly womenPE risk stratificationTransient provoking factorsRelevant clinical characteristicsSex differencesWarrants further investigationSex-related differencesSex-specific factorsClot burdenPE presentationChest painHormonal therapyHormone therapyPatient characteristicsPulmonary embolismYounger patientsAtherosclerotic diseaseRisk stratificationLung diseaseMedicare databaseProvoking factorsCardiovascular disease
2022
Sex-Specific Risk Factors Associated With First Acute Myocardial Infarction in Young Adults
Lu Y, Li SX, Liu Y, Rodriguez F, Watson KE, Dreyer RP, Khera R, Murugiah K, D’Onofrio G, Spatz ES, Nasir K, Masoudi FA, Krumholz HM. Sex-Specific Risk Factors Associated With First Acute Myocardial Infarction in Young Adults. JAMA Network Open 2022, 5: e229953. PMID: 35503221, PMCID: PMC9066284, DOI: 10.1001/jamanetworkopen.2022.9953.Peer-Reviewed Original ResearchConceptsFirst acute myocardial infarctionAcute myocardial infarctionPsychosocial risk factorsRisk factor profilePopulation attributable fractionRisk factor associationsRisk factorsOdds ratioYoung womenAMI subtypesMyocardial infarctionPrevention of AMIType 1 acute myocardial infarctionFactor profileRisk of AMITraditional cardiovascular risk factorsSex-specific risk factorsFactor associationsYoung adultsRisk factor modificationCardiovascular risk factorsStrong associationNutrition Examination SurveyCase-control studyPopulation-based controlsDepression and Perceived Stress After Spontaneous Coronary Artery Dissection and Comparison With Other Acute Myocardial Infarction (the VIRGO Experience)
Murugiah K, Chen L, Dreyer RP, Bouras G, Safdar B, Lu Y, Spatz ES, Gupta A, Khera R, Ng VG, Bueno H, Tweet MS, Spertus JA, Hayes SN, Lansky A, Krumholz HM. Depression and Perceived Stress After Spontaneous Coronary Artery Dissection and Comparison With Other Acute Myocardial Infarction (the VIRGO Experience). The American Journal Of Cardiology 2022, 173: 33-38. PMID: 35365290, PMCID: PMC9133198, DOI: 10.1016/j.amjcard.2022.03.005.Peer-Reviewed Original ResearchConceptsSpontaneous coronary artery dissectionPatient Health Questionnaire-9Coronary artery dissectionPSS-14 scoreArtery dissectionBaseline PHQ-9 scoreAcute myocardial infarction patientsCardiovascular risk factorsPHQ-9 scoresAcute myocardial infarctionMyocardial infarction patientsYears of agePerceived Stress Scale scoresStress Scale scoresLinear mixed-effects analysisSCAD casesVIRGO StudyQuestionnaire-9Infarction patientsMixed-effects analysisMyocardial infarctionSubgroup analysisRisk factorsRoutine screeningClinical acuity
2017
Sex Differences in Inflammatory Markers and Health Status Among Young Adults With Acute Myocardial Infarction
Lu Y, Zhou S, Dreyer RP, Spatz ES, Geda M, Lorenze NP, D'Onofrio G, Lichtman JH, Spertus JA, Ridker PM, Krumholz HM. Sex Differences in Inflammatory Markers and Health Status Among Young Adults With Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2017, 10: e003470. PMID: 28228461, PMCID: PMC5459381, DOI: 10.1161/circoutcomes.116.003470.Peer-Reviewed Original ResearchMeSH Keywords1-Alkyl-2-acetylglycerophosphocholine EsteraseAdolescentAdultAge of OnsetBiomarkersChi-Square DistributionComorbidityC-Reactive ProteinFemaleHealth Status DisparitiesHumansInflammation MediatorsLinear ModelsMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionProspective StudiesRisk AssessmentRisk FactorsSex FactorsSocioeconomic FactorsUnited StatesUp-RegulationYoung AdultConceptsHigh-sensitivity C-reactive proteinAcute myocardial infarctionHigher inflammatory levelsInflammatory markersPoor health statusHealth statusYoung womenMyocardial infarctionInflammatory levelsTargeted anti-inflammatory treatmentsElevated inflammatory markersResidual cholesterol riskResidual inflammatory riskSex differencesAnti-inflammatory treatmentAnti-inflammatory therapyC-reactive proteinHigher mortality riskYoung menPhospholipase A2Years of ageCardiovascular outcomesMultivariable adjustmentPatient characteristicsSecondary prevention
2016
Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants
Zhou B, Bentham J, Di Cesare M, Bixby H, Danaei G, Cowan M, Paciorek C, Singh G, Hajifathalian K, Bennett J, Taddei C, Bilano V, Carrillo-Larco R, Djalalinia S, Khatibzadeh S, Lugero C, Peykari N, Zhang W, Lu Y, Stevens G, Riley L, Bovet P, Elliott P, Gu D, Ikeda N, Jackson R, Joffres M, Kengne A, Laatikainen T, Lam T, Laxmaiah A, Liu J, Miranda J, Mondo C, Neuhauser H, Sundström J, Smeeth L, Soric M, Woodward M, Ezzati M, Abarca-Gómez L, Abdeen Z, Rahim H, Abu-Rmeileh N, Acosta-Cazares B, Adams R, Aekplakorn W, Afsana K, Aguilar-Salinas C, Agyemang C, Ahmadvand A, Ahrens W, Al Raddadi R, Al Woyatan R, Ali M, Alkerwi A, Aly E, Amouyel P, Amuzu A, Andersen L, Anderssen S, Ängquist L, Anjana R, Ansong D, Aounallah-Skhiri H, Araújo J, Ariansen I, Aris T, Arlappa N, Aryal K, Arveiler D, Assah F, Assunção M, Avdicová M, Azevedo A, Azizi F, Babu B, Bahijri S, Balakrishna N, Bandosz P, Banegas J, Barbagallo C, Barceló A, Barkat A, Barros A, Barros M, Bata I, Batieha A, Baur L, Beaglehole R, Romdhane H, Benet M, Benson L, Bernabe-Ortiz A, Bernotiene G, Bettiol H, Bhagyalaxmi A, Bharadwaj S, Bhargava S, Bi Y, Bikbov M, Bjerregaard P, Bjertness E, Björkelund C, Blokstra A, Bo S, Bobak M, Boeing H, Boggia J, Boissonnet C, Bongard V, Braeckman L, Brajkovich I, Branca F, Breckenkamp J, Brenner H, Brewster L, Bruno G, Bueno-de-Mesquita H, Bugge A, Burns C, Bursztyn M, de León A, Cacciottolo J, Cameron C, Can G, Cândido A, Capuano V, Cardoso V, Carlsson A, Carvalho M, Casanueva F, Casas J, Caserta C, Chamukuttan S, Chan A, Chan Q, Chaturvedi H, Chaturvedi N, Chen C, Chen F, Chen H, Chen S, Chen Z, Cheng C, Dekkaki I, Chetrit A, Chiolero A, Chiou S, Chirita-Emandi A, Cho B, Cho Y, Chudek J, Cifkova R, Claessens F, Clays E, Concin H, Cooper C, Cooper R, Coppinger T, Costanzo S, Cottel D, Cowell C, Craig C, Crujeiras A, Cruz J, D'Arrigo G, d'Orsi E, Dallongeville J, Damasceno A, Dankner R, Dantoft T, Dauchet L, De Backer G, De Bacquer D, de Gaetano G, De Henauw S, De Smedt D, Deepa M, Dehghan A, Delisle H, Deschamps V, Dhana K, Di Castelnuovo A, Dias-da-Costa J, Diaz A, Dickerson T, Do H, Dobson A, Donfrancesco C, Donoso S, Döring A, Doua K, Drygas W, Dulskiene V, Džakula A, Dzerve V, Dziankowska-Zaborszczyk E, Eggertsen R, Ekelund U, El Ati J, Ellert U, Elliott P, Elosua R, Erasmus R, Erem C, Eriksen L, de la Peña J, Evans A, Faeh D, Fall C, Farzadfar F, Felix-Redondo F, Ferguson T, Fernández-Bergés D, Ferrante D, Ferrari M, Ferreccio C, Ferrieres J, Finn J, Fischer K, Föger B, Foo L, Forslund A, Forsner M, Fortmann S, Fouad H, Francis D, Franco M, Franco O, Frontera G, Fuchs F, Fuchs S, Fujita Y, Furusawa T, Gaciong Z, Gareta D, Garnett S, Gaspoz J, Gasull M, Gates L, Gavrila D, Geleijnse J, Ghasemian A, Ghimire A, Giampaoli S, Gianfagna F, Giovannelli J, Goldsmith R, Gonçalves H, Gross M, Rivas J, Gottrand F, Graff-Iversen S, Grafnetter D, Grajda A, Gregor R, Grodzicki T, Grøntved A, Gruden G, Grujic V, Gu D, Guan O, Gudnason V, Guerrero R, Guessous I, Guimaraes A, Gulliford M, Gunnlaugsdottir J, Gunter M, Gupta P, Gureje O, Gurzkowska B, Gutierrez L, Gutzwiller F, Hadaegh F, Halkjær J, Hambleton I, Hardy R, Harikumar R, Hata J, Hayes A, He J, Hendriks M, Henriques A, Cadena L, Herrala S, Heshmat R, Hihtaniemi I, Ho S, Ho S, Hobbs M, Hofman A, Dinc G, Hormiga C, Horta B, Houti L, Howitt C, Htay T, Htet A, Hu Y, Huerta J, Husseini A, Huybrechts I, Hwalla N, Iacoviello L, Iannone A, Ibrahim M, Ikram M, Irazola V, Islam M, Ivkovic V, Iwasaki M, Jackson R, Jacobs J, Jafar T, Jamrozik K, Janszky I, Jasienska G, Jelakovic B, Jiang C, Joffres M, Johansson M, Jonas J, Jørgensen T, Joshi P, Juolevi A, Jurak G, Jureša V, Kaaks R, Kafatos A, Kalter-Leibovici O, Kamaruddin N, Kasaeian A, Katz J, Kauhanen J, Kaur P, Kavousi M, Kazakbaeva G, Keil U, Boker L, Keinänen-Kiukaanniemi S, Kelishadi R, Kemper H, Kengne A, Kersting M, Key T, Khader Y, Khalili D, Khang Y, Khaw K, Kiechl S, Killewo J, Kim J, Klumbiene J, Kolle E, Kolsteren P, Korrovits P, Koskinen S, Kouda K, Koziel S, Kristensen P, Krokstad S, Kromhout D, Kruger H, Kubinova R, Kuciene R, Kuh D, Kujala U, Kula K, Kulaga Z, Kumar R, Kurjata P, Kusuma Y, Kuulasmaa K, Kyobutungi C, Laatikainen T, Lachat C, Lam T, Landrove O, Lanska V, Lappas G, Larijani B, Laugsand L, Laxmaiah A, Bao K, Le T, Leclercq C, Lee J, Lee J, Lehtimäki T, Lekhraj R, León-Muñoz L, Levitt N, Li Y, Lilly C, Lim W, Lima-Costa M, Lin H, Lin X, Linneberg A, Lissner L, Litwin M, Lorbeer R, Lotufo P, Lozano J, Luksiene D, Lundqvist A, Lunet N, Lytsy P, Ma G, Ma J, Machado-Coelho G, Machi S, Maggi S, Magliano D, Majer M, Makdisse M, Malekzadeh R, Malhotra R, Rao K, Malyutina S, Manios Y, Mann J, Manzato E, Margozzini P, Marques-Vidal P, Marrugat J, Martorell R, Mathiesen E, Matijasevich A, Matsha T, Mbanya J, Posso A, McFarlane S, McGarvey S, McLachlan S, McLean R, McNulty B, Khir A, Mediene-Benchekor S, Medzioniene J, Meirhaeghe A, Meisinger C, Menezes A, Menon G, Meshram I, Metspalu A, Mi J, Mikkel K, Miller J, Miquel J, Mišigoj-Durakovic M, Mohamed M, Mohammad K, Mohammadifard N, Mohan V, Yusoff M, Møller N, Molnár D, Momenan A, Mondo C, Monyeki K, Moreira L, Morejon A, Moreno L, Morgan K, Moschonis G, Mossakowska M, Mostafa A, Mota J, Motlagh M, Motta J, Muiesan M, Müller-Nurasyid M, Murphy N, Mursu J, Musil V, Nagel G, Naidu B, Nakamura H, Námešná J, Nang E, Nangia V, Narake S, Navarrete-Muñoz E, Ndiaye N, Neal W, Nenko I, Nervi F, Nguyen N, Nguyen Q, Nieto-Martínez R, Niiranen T, Ning G, Ninomiya T, Nishtar S, Noale M, Noboa O, Noorbala A, Noorbala T, Noto D, Al Nsour M, O'Reilly D, Oh K, Olinto M, Oliveira I, Omar M, Onat A, Ordunez P, Osmond C, Ostojic S, Otero J, Overvad K, Owusu-Dabo E, Paccaud F, Padez C, Pahomova E, Pajak A, Palli D, Palmieri L, Panda-Jonas S, Panza F, Papandreou D, Parnell W, Parsaeian M, Pecin I, Pednekar M, Peer N, Peeters P, Peixoto S, Pelletier C, Peltonen M, Pereira A, Pérez R, Peters A, Petkeviciene J, Pham S, Pigeot I, Pikhart H, Pilav A, Pilotto L, Pitakaka F, Plans-Rubió P, Polakowska M, Polašek O, Porta M, Portegies M, Pourshams A, Pradeepa R, Prashant M, Price J, Puiu M, Punab M, Qasrawi R, Qorbani M, Radic I, Radisauskas R, Rahman M, Raitakari O, Raj M, Rao S, Ramachandran A, Ramos E, Rampal S, Reina D, Rasmussen F, Redon J, Reganit P, Ribeiro R, Riboli E, Rigo F, de Wit T, Ritti-Dias R, Robinson S, Robitaille C, Rodríguez-Artalejo F, Rodriguez-Perez del Cristo M, Rodríguez-Villamizar L, Rojas-Martinez R, Rosengren A, Rubinstein A, Rui O, Ruiz-Betancourt B, Horimoto A, Rutkowski M, Sabanayagam C, Sachdev H, Saidi O, Sakarya S, Salanave B, Salazar Martinez E, Salmerón D, Salomaa V, Salonen J, Salvetti M, Sánchez-Abanto J, Sans S, Santos D, Santos I, dos Santos R, Santos R, Saramies J, Sardinha L, Margolis G, Sarrafzadegan N, Saum K, Savva S, Scazufca M, Schargrodsky H, Schneider I, Schultsz C, Schutte A, Sen A, Senbanjo I, Sepanlou S, Sharma S, Shaw J, Shibuya K, Shin D, Shin Y, Siantar R, Sibai A, Silva D, Simon M, Simons J, Simons L, Sjöström M, Skovbjerg S, Slowikowska-Hilczer J, Slusarczyk P, Smeeth L, Smith M, Snijder M, So H, Sobngwi E, Söderberg S, Solfrizzi V, Sonestedt E, Song Y, Sørensen T, Jérome C, Soumare A, Staessen J, Starc G, Stathopoulou M, Stavreski B, Steene-Johannessen J, Stehle P, Stein A, Stergiou G, Stessman J, Stieber J, Stöckl D, Stocks T, Stokwiszewski J, Stronks K, Strufaldi M, Sun C, Sundström J, Sung Y, Suriyawongpaisal P, Sy R, Tai E, Tammesoo M, Tamosiunas A, Tang L, Tang X, Tanser F, Tao Y, Tarawneh M, Tarqui-Mamani C, Taylor A, Theobald H, Thijs L, Thuesen B, Tjonneland A, Tolonen H, Tolstrup J, Topbas M, Topór-Madry R, Tormo M, Torrent M, Traissac P, Trichopoulos D, Trichopoulou A, Trinh O, Trivedi A, Tshepo L, Tulloch-Reid M, Tuomainen T, Tuomilehto J, Turley M, Tynelius P, Tzourio C, Ueda P, Ugel E, Ulmer H, Uusitalo H, Valdivia G, Valvi D, van der Schouw Y, Van Herck K, van Rossem L, van Valkengoed I, Vanderschueren D, Vanuzzo D, Vatten L, Vega T, Velasquez-Melendez G, Veronesi G, Verschuren W, Verstraeten R, Victora C, Viet L, Viikari-Juntura E, Vineis P, Vioque J, Virtanen J, Visvikis-Siest S, Viswanathan B, Vollenweider P, Voutilainen S, Vrdoljak A, Vrijheid M, Wade A, Wagner A, Walton J, Mohamud W, Wang M, Wang Q, Wang Y, Wannamethee S, Wareham N, Wedderkopp N, Weerasekera D, Whincup P, Widhalm K, Widyahening I, Wiecek A, Wijga A, Wilks R, Willeit J, Willeit P, Williams E, Wilsgaard T, Wojtyniak B, Wong T, Wong-McClure R, Woo J, Woodward M, Wu A, Wu F, Wu S, Xu H, Yan W, Yang X, Ye X, Yiallouros P, Yoshihara A, Younger-Coleman N, Yusoff A, Yusoff M, Zambon S, Zdrojewski T, Zeng Y, Zhao D, Zhao W, Zheng Y, Zhu D, Zimmermann E, Zuñiga Cisneros J. Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants. The Lancet 2016, 389: 37-55. PMID: 27863813, PMCID: PMC5220163, DOI: 10.1016/s0140-6736(16)31919-5.Peer-Reviewed Original ResearchConceptsDiastolic blood pressureBlood pressure levelsSystolic blood pressureBlood pressureMean systolicMiddle-income countriesGlobal age-standardised prevalenceMean diastolic blood pressureMean systolic blood pressureHigher blood pressure levelsNumber of adultsAge-standardised prevalenceChronic kidney diseaseMean blood pressurePopulation-based studyAge-specific prevalenceImportant risk factorSaharan AfricaKidney diseasePooled analysisRisk factorsCardiovascular diseaseHigh-income countriesPrevalencePressure levels
2015
Mediators of the Effect of Body Mass Index on Coronary Heart Disease
Lu Y, Hajifathalian K, Rimm EB, Ezzati M, Danaei G. Mediators of the Effect of Body Mass Index on Coronary Heart Disease. Epidemiology 2015, 26: 153-162. PMID: 25643095, DOI: 10.1097/ede.0000000000000234.Peer-Reviewed Original ResearchConceptsBody mass indexCoronary heart diseaseExcess relative riskHigh-sensitive C-reactive proteinHigher body mass indexC-reactive proteinBlood pressureRelative riskMass indexBlood glucoseHeart diseaseRisk factorsMetabolic risk factorsProspective cohort studyPrevalence of overweightMajor risk factorRandom-effects modelProthrombotic biomarkersCHD eventsCohort studyInflammatory biomarkersObese participantsMetabolic mediatorsMetabolic factorsMultiplicative scale
2013
Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1·8 million participants
Lu Y, Hajifathalian K, Ezzati M, Woodward M, Rimm E, Danaei G. Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1·8 million participants. The Lancet 2013, 383: 970-983. PMID: 24269108, PMCID: PMC3959199, DOI: 10.1016/s0140-6736(13)61836-x.Peer-Reviewed Original ResearchConceptsBody mass indexCoronary heart diseaseHigher body mass indexHazard ratioBlood pressureExcess riskHeart diseaseEffect of BMIImperial College Healthcare NHS TrustMetabolic risk factorsProspective cohort studyAverage blood pressureHigh blood pressureCardiovascular disease preventionUK Medical Research CouncilNational InstituteRandom-effects modelMedical Research CouncilBiomedical Research CentreCohort studyProspective cohortStroke eventsNormal weightPooled analysisUS National InstitutesThe State of US Health, 1990-2010: Burden of Diseases, Injuries, and Risk Factors
Murray CJ, Atkinson C, Bhalla K, Birbeck G, Burstein R, Chou D, Dellavalle R, Danaei G, Ezzati M, Fahimi A, Flaxman D, Foreman, Gabriel S, Gakidou E, Kassebaum N, Khatibzadeh S, Lim S, Lipshultz SE, London S, Lopez, MacIntyre MF, Mokdad AH, Moran A, Moran AE, Mozaffarian D, Murphy T, Naghavi M, Pope C, Roberts T, Salomon J, Schwebel DC, Shahraz S, Sleet DA, Murray, Abraham J, Ali MK, Atkinson C, Bartels DH, Bhalla K, Birbeck G, Burstein R, Chen H, Criqui MH, Dahodwala, Jarlais, Ding EL, Dorsey ER, Ebel BE, Ezzati M, Fahami, Flaxman S, Flaxman AD, Gonzalez-Medina D, Grant B, Hagan H, Hoffman H, Kassebaum N, Khatibzadeh S, Leasher JL, Lin J, Lipshultz SE, Lozano R, Lu Y, Mallinger L, McDermott MM, Micha R, Miller TR, Mokdad AA, Mokdad AH, Mozaffarian D, Naghavi M, Narayan KM, Omer SB, Pelizzari PM, Phillips D, Ranganathan D, Rivara FP, Roberts T, Sampson U, Sanman E, Sapkota A, Schwebel DC, Sharaz S, Shivakoti R, Singh GM, Singh D, Tavakkoli M, Towbin JA, Wilkinson JD, Zabetian A, Murray, Abraham J, Ali MK, Alvardo M, Atkinson C, Baddour LM, Benjamin EJ, Bhalla K, Birbeck G, Bolliger I, Burstein R, Carnahan E, Chou D, Chugh SS, Cohen A, Colson KE, Cooper LT, Couser W, Criqui MH, Dabhadkar KC, Dellavalle RP, Jarlais, Dicker D, Dorsey ER, Duber H, Ebel BE, Engell RE, Ezzati M, Felson DT, Finucane MM, Flaxman S, Flaxman AD, Fleming T, Foreman, Forouzanfar MH, Freedman G, Freeman MK, Gakidou E, Gillum RF, Gonzalez-Medina D, Gosselin R, Gutierrez HR, Hagan H, Havmoeller R, Hoffman H, Jacobsen KH, James SL, Jasrasaria R, Jayarman S, Johns N, Kassebaum N, Khatibzadeh S, Lan Q, Leasher JL, Lim S, Lipshultz SE, London S, Lopez, Lozano R, Lu Y, Mallinger L, Meltzer M, Mensah GA, Michaud C, Miller TR, Mock C, Moffitt TE, Mokdad AA, Mokdad AH, Moran A, Naghavi M, Narayan KM, Nelson RG, Olives C, Omer SB, Ortblad K, Ostro B, Pelizzari PM, Phillips D, Raju M, Razavi H, Ritz B, Roberts T, Sacco RL, Salomon J, Sampson U, Schwebel DC, Shahraz S, Shibuya K, Silberberg D, Singh JA, Steenland K, Taylor JA, Thurston GD, Vavilala MS, Vos T, Wagner GR, Weinstock MA, Weisskopf MG, Wulf S, Murray. The State of US Health, 1990-2010: Burden of Diseases, Injuries, and Risk Factors. JAMA 2013, 310: 591-606. PMID: 23842577, PMCID: PMC5436627, DOI: 10.1001/jama.2013.13805.Peer-Reviewed Original ResearchConceptsAge-standardized YLL rateHealthy life expectancyBurden of diseaseRisk factorsLife expectancyPopulation healthYLL ratesAge-standardized YLD rateChronic obstructive pulmonary diseaseHigher body mass indexAge-standardized death ratesDeath rateReference life expectancyRisk-outcome pairsSum of YLDsChronic kidney diseaseObstructive pulmonary diseaseHigh blood pressureIschemic heart diseaseBody mass indexLow back painDrug use disordersDisease 2010 studyMajor depressive disorderMajor health problem
2012
A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H, AlMazroa M, Amann M, Anderson H, Andrews K, Aryee M, Atkinson C, Bacchus L, Bahalim A, Balakrishnan K, Balmes J, Barker-Collo S, Baxter A, Bell M, Blore J, Blyth F, Bonner C, Borges G, Bourne R, Boussinesq M, Brauer M, Brooks P, Bruce N, Brunekreef B, Bryan-Hancock C, Bucello C, Buchbinder R, Bull F, Burnett R, Byers T, Calabria B, Carapetis J, Carnahan E, Chafe Z, Charlson F, Chen H, Chen J, Cheng A, Child J, Cohen A, Colson K, Cowie B, Darby S, Darling S, Davis A, Degenhardt L, Dentener F, Jarlais D, Devries K, Dherani M, Ding E, Dorsey E, Driscoll T, Edmond K, Ali S, Engell R, Erwin P, Fahimi S, Falder G, Farzadfar F, Ferrari A, Finucane M, Flaxman S, Fowkes F, Freedman G, Freeman M, Gakidou E, Ghosh S, Giovannucci E, Gmel G, Graham K, Grainger R, Grant B, Gunnell D, Gutierrez H, Hall W, Hoek H, Hogan A, Hosgood H, Hoy D, Hu H, Hubbell B, Hutchings S, Ibeanusi S, Jacklyn G, Jasrasaria R, Jonas J, Kan H, Kanis J, Kassebaum N, Kawakami N, Khang Y, Khatibzadeh S, Khoo J, Kok C, Laden F, Lalloo R, Lan Q, Lathlean T, Leasher J, Leigh J, Li Y, Lin J, Lipshultz S, London S, Lozano R, Lu Y, Mak J, Malekzadeh R, Mallinger L, Marcenes W, March L, Marks R, Martin R, McGale P, McGrath J, Mehta S, Memish Z, Mensah G, Merriman T, Micha R, Michaud C, Mishra V, Hanafiah K, Mokdad A, Morawska L, Mozaffarian D, Murphy T, Naghavi M, Neal B, Nelson P, Nolla J, Norman R, Olives C, Omer S, Orchard J, Osborne R, Ostro B, Page A, Pandey K, Parry C, Passmore E, Patra J, Pearce N, Pelizzari P, Petzold M, Phillips M, Pope D, Pope C, Powles J, Rao M, Razavi H, Rehfuess E, Rehm J, Ritz B, Rivara F, Roberts T, Robinson C, Rodriguez-Portales J, Romieu I, Room R, Rosenfeld L, Roy A, Rushton L, Salomon J, Sampson U, Sanchez-Riera L, Sanman E, Sapkota A, Seedat S, Shi P, Shield K, Shivakoti R, Singh G, Sleet D, Smith E, Smith K, Stapelberg N, Steenland K, Stöckl H, Stovner L, Straif K, Straney L, Thurston G, Tran J, Van Dingenen R, van Donkelaar A, Veerman J, Vijayakumar L, Weintraub R, Weissman M, White R, Whiteford H, Wiersma S, Wilkinson J, Williams H, Williams W, Wilson N, Woolf A, Yip P, Zielinski J, Lopez A, Murray C, Ezzati M. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet 2012, 380: 2224-2260. PMID: 23245609, PMCID: PMC4156511, DOI: 10.1016/s0140-6736(12)61766-8.Peer-Reviewed Original ResearchConceptsSecond-hand smokeDisease Study 2010High blood pressureRisk factorsDisease burdenGlobal disease burdenTobacco smokingRisk factor exposureBlood pressureGlobal DALYsChildhood underweightRelative riskGlobal burdenStudy 2010Unimproved waterCommunicable diseasesHigher body mass indexHigh-income North AmericaAlcohol useChildhood communicable diseasesDisability-adjusted life yearsRisk factor clustersDietary risk factorsCause-specific deathBody mass index