2023
Quantifying Blood Pressure Visit-to-Visit Variability in the Real-World Setting: A Retrospective Cohort Study
Lu Y, Linderman G, Mahajan S, Liu Y, Huang C, Khera R, Mortazavi B, Spatz E, Krumholz H. Quantifying Blood Pressure Visit-to-Visit Variability in the Real-World Setting: A Retrospective Cohort Study. Circulation Cardiovascular Quality And Outcomes 2023, 16: e009258. PMID: 36883456, DOI: 10.1161/circoutcomes.122.009258.Peer-Reviewed Original ResearchConceptsRetrospective cohort studyBlood pressure valuesPatient characteristicsReal-world settingCohort studyPatient subgroupsYale New Haven Health SystemMean body mass indexSystolic blood pressure valuesBlood pressure visitHistory of hypertensionCoronary artery diseaseManagement of patientsMultivariable linear regression modelsBlood pressure readingsBody mass indexPatient-level measuresBlood pressure variationAbsolute standardized differencesNon-Hispanic whitesAntihypertensive medicationsReal-world practiceVisit variabilityArtery diseaseRegression models
2022
Hemodynamic differences between women and men with elevated blood pressure in China: A non-invasive assessment of 45,082 adults using impedance cardiography
Caraballo C, Mahajan S, Gu J, Lu Y, Spatz ES, Dreyer RP, Zhang M, Sun N, Ren Y, Zheng X, Zhao H, Lu H, J. Z, Krumholz HM. Hemodynamic differences between women and men with elevated blood pressure in China: A non-invasive assessment of 45,082 adults using impedance cardiography. PLOS ONE 2022, 17: e0269777. PMID: 35700163, PMCID: PMC9197037, DOI: 10.1371/journal.pone.0269777.Peer-Reviewed Original ResearchConceptsElevated blood pressureSystemic vascular resistance indexVascular resistance indexBlood pressureCardiac indexResistance indexHigh systemic vascular resistance indexLower systemic vascular resistance indexHigher mean systolic blood pressureMean diastolic blood pressureMean systolic blood pressureImpedance cardiographyLow cardiac indexHigher cardiac indexDiastolic blood pressureSystolic blood pressureBody mass indexYear old womanPersonalization of treatmentSame age groupNon-invasive assessmentSex differencesHemodynamic profileMass indexHemodynamic differences
2021
Effectiveness of an impedance cardiography guided treatment strategy to improve blood pressure control in a real-world setting: results from a pragmatic clinical trial
Wang L, Lu Y, Wang H, Gu J, J Z, Lian Z, Zhang Z, Krumholz H, Sun N. Effectiveness of an impedance cardiography guided treatment strategy to improve blood pressure control in a real-world setting: results from a pragmatic clinical trial. Open Heart 2021, 8: e001719. PMID: 34580169, PMCID: PMC8477318, DOI: 10.1136/openhrt-2021-001719.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAntihypertensive AgentsBlood PressureCardiography, ImpedanceChinaClinical Decision-MakingFemaleFollow-Up StudiesHumansHypertensionIncidenceMaleMiddle AgedPractice Guidelines as TopicRetrospective StudiesTherapy, Computer-AssistedTime FactorsTreatment OutcomeYoung AdultConceptsBody mass indexPeking University People's HospitalStandard care groupBlood pressure controlSystolic BPHaemodynamic groupsTreatment strategiesImpedance cardiographyBaseline BPBP goalHypertension clinicHaemodynamic profileBP levelsCare groupPeople's HospitalMean baseline systolic BPPressure controlReal-world clinical practiceBaseline systolic BPMean systolic BPDiastolic BP levelsProportion of patientsPragmatic clinical trialsReal-world populationBaseline DBP
2017
Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults
Abarca-Gómez L, Abdeen Z, Hamid Z, Abu-Rmeileh N, Acosta-Cazares B, Acuin C, Adams R, Aekplakorn W, Afsana K, Aguilar-Salinas C, Agyemang C, Ahmadvand A, Ahrens W, Ajlouni K, Akhtaeva N, Al-Hazzaa H, Al-Othman A, Al-Raddadi R, Al Buhairan F, Al Dhukair S, Ali M, Ali O, Alkerwi A, Alvarez-Pedrerol M, Aly E, Amarapurkar D, Amouyel P, Amuzu A, Andersen L, Anderssen S, Andrade D, Ängquist L, Anjana R, Aounallah-Skhiri H, Araújo J, Ariansen I, Aris T, Arlappa N, Arveiler D, Aryal K, Aspelund T, Assah F, Assunção M, Aung M, Avdicová M, Azevedo A, Azizi F, Babu B, Bahijri S, Baker J, Balakrishna N, Bamoshmoosh M, Banach M, Bandosz P, Banegas J, Barbagallo C, Barceló A, Barkat A, Barros A, Barros M, Bata I, Batieha A, Batista R, Batyrbek A, Baur L, Beaglehole R, Romdhane H, Benedics J, Benet M, Bennett J, Bernabe-Ortiz A, Bernotiene G, Bettiol H, Bhagyalaxmi A, Bharadwaj S, Bhargava S, Bhatti Z, Bhutta Z, Bi H, Bi Y, Biehl A, Bikbov M, Bista B, Bjelica D, Bjerregaard P, Bjertness E, Bjertness M, Björkelund C, Blokstra A, Bo S, Bobak M, Boddy L, Boehm B, Boeing H, Boggia J, Boissonnet C, Bonaccio M, Bongard V, Bovet P, Braeckevelt L, Braeckman L, Bragt M, Brajkovich I, Branca F, Breckenkamp J, Breda J, Brenner H, Brewster L, Brian G, Brinduse L, Bruno G, Bueno-de-Mesquita H, Bugge A, Buoncristiano M, Burazeri G, Burns C, de León A, Cacciottolo J, Cai H, Cama T, Cameron C, Camolas J, Can G, Cândido A, Capanzana M, Capuano V, Cardoso V, Carlsson A, Carvalho M, Casanueva F, Casas J, Caserta C, Chamukuttan S, Chan A, Chan Q, Chaturvedi H, Chaturvedi N, Chen C, Chen F, Chen H, Chen S, Chen Z, Cheng C, Chetrit A, Chikova-Iscener E, Chiolero A, Chiou S, Chirita-Emandi A, Chirlaque M, Cho B, Cho Y, Christensen K, Christofaro D, Chudek J, Cifkova R, Cinteza E, Claessens F, Clays E, Concin H, Confortin S, Cooper C, Cooper R, Coppinger T, Costanzo S, Cottel D, Cowell C, Craig C, Crujeiras A, Cucu A, D'Arrigo G, d'Orsi E, Dallongeville J, Damasceno A, Damsgaard C, Danaei G, Dankner R, Dantoft T, Dastgiri S, Dauchet L, Davletov K, De Backer G, De Bacquer D, De Curtis A, de Gaetano G, De Henauw S, de Oliveira P, De Ridder K, De Smedt D, Deepa M, Deev A, Dehghan A, Delisle H, Delpeuch F, Deschamps V, Dhana K, Di Castelnuovo A, Dias-da-Costa J, Diaz A, Dika Z, Djalalinia S, Do H, Dobson A, Donati M, Donfrancesco C, Donoso S, Döring A, Dorobantu M, Dorosty A, Doua K, Drygas W, Duan J, Duante C, Duleva V, Dulskiene V, Dzerve V, Dziankowska-Zaborszczyk E, Egbagbe E, Eggertsen R, Eiben G, Ekelund U, El Ati J, Elliott P, Engle-Stone R, Erasmus R, Erem C, Eriksen L, Eriksson J, la Peña J, Evans A, Faeh D, Fall C, Sant'Angelo V, Farzadfar F, Felix-Redondo F, Ferguson T, Fernandes R, Fernández-Bergés D, Ferrante D, Ferrari M, Ferreccio C, Ferrieres J, Finn J, Fischer K, Flores E, Föger B, Foo L, Forslund A, Forsner M, Fouad H, Francis D, Franco M, Franco O, Frontera G, Fuchs F, Fuchs S, Fujita Y, Furusawa T, Gaciong Z, Gafencu M, Galeone D, Galvano F, Garcia-de-la-Hera M, Gareta D, Garnett S, Gaspoz J, Gasull M, Gates L, Geiger H, Geleijnse J, Ghasemian A, Giampaoli S, Gianfagna F, Gill T, Giovannelli J, Giwercman A, Godos J, Gogen S, Goldsmith R, Goltzman D, Gonçalves H, González-Leon M, González-Rivas J, Gonzalez-Gross M, Gottrand F, Graça A, Graff-Iversen S, Grafnetter D, Grajda A, Grammatikopoulou M, Gregor R, Grodzicki T, Grøntved A, Grosso G, Gruden G, Grujic V, Gu D, Gualdi-Russo E, Guallar-Castillón P, Guan O, Gudmundsson E, Gudnason V, Guerrero R, Guessous I, Guimaraes A, Gulliford M, Gunnlaugsdottir J, Gunter M, Guo X, Guo Y, Gupta P, Gupta R, Gureje O, Gurzkowska B, Gutierrez L, Gutzwiller F, Hadaegh F, Hadjigeorgiou C, Si-Ramlee K, Halkjær J, Hambleton I, Hardy R, Kumar R, Hassapidou M, Hata J, Hayes A, He J, Heidinger-Felso R, Heinen M, Hendriks M, Henriques A, Cadena L, Herrala S, Herrera V, Herter-Aeberli I, Heshmat R, Hihtaniemi I, Ho S, Ho S, Hobbs M, Hofman A, Hopman W, Horimoto A, Hormiga C, Horta B, Houti L, Howitt C, Htay T, Htet A, Htike M, Hu Y, Huerta J, Petrescu C, Huisman M, Husseini A, Huu C, Huybrechts I, Hwalla N, Hyska J, Iacoviello L, Iannone A, Ibarluzea J, Ibrahim M, Ikeda N, Ikram M, Irazola V, Islam M, Ismail A, Ivkovic V, Iwasaki M, Jackson R, Jacobs J, Jaddou H, Jafar T, Jamil K, Jamrozik K, Janszky I, Jarani J, Jasienska G, Jelakovic A, Jelakovic B, Jennings G, Jeong S, Jiang C, Jiménez-Acosta S, Joffres M, Johansson M, Jonas J, Jørgensen T, Joshi P, Jovic D, Józwiak J, Juolevi A, Jurak G, Jureša V, Kaaks R, Kafatos A, Kajantie E, Kalter-Leibovici O, Kamaruddin N, Kapantais E, Karki K, Kasaeian A, Katz J, Kauhanen J, Kaur P, Kavousi M, Kazakbaeva G, Keil U, Boker L, Keinänen-Kiukaanniemi S, Kelishadi R, Kelleher C, Kemper H, Kengne A, Kerimkulova A, Kersting M, Key T, Khader Y, Khalili D, Khang Y, Khateeb M, Khaw K, Khouw I, Kiechl-Kohlendorfer U, Kiechl S, Killewo J, Kim J, Kim Y, Klimont J, Klumbiene J, Knoflach M, Koirala B, Kolle E, Kolsteren P, Korrovits P, Kos J, Koskinen S, Kouda K, Kovacs V, Kowlessur S, Koziel S, Kratzer W, Kriemler S, Kristensen P, Krokstad S, Kromhout D, Kruger H, Kubinova R, Kuciene R, Kuh D, Kujala U, Kulaga Z, Kumar R, Kunešová M, Kurjata P, Kusuma Y, Kuulasmaa K, Kyobutungi C, La Q, Laamiri F, Laatikainen T, Lachat C, Laid Y, Lam T, Landrove O, Lanska V, Lappas G, Larijani B, Laugsand L, Lauria L, Laxmaiah A, Bao K, Le T, Lebanan M, Leclercq C, Lee J, Lee J, Lehtimäki T, León-Muñoz L, Levitt N, Li Y, Lilly C, Lim W, Lima-Costa M, Lin H, Lin X, Lind L, Linneberg A, Lissner L, Litwin M, Liu J, Loit H, Lopes L, Lorbeer R, Lotufo P, Lozano J, Luksiene D, Lundqvist A, Lunet N, Lytsy P, Ma G, Ma J, Machado-Coelho G, Machado-Rodrigues A, Machi S, Maggi S, Magliano D, Magriplis E, Mahaletchumy A, Maire B, Majer M, Makdisse M, Malekzadeh R, Malhotra R, Rao K, Malyutina S, Manios Y, Mann J, Manzato E, Margozzini P, Markaki A, Markey O, Marques L, Marques-Vidal P, Marrugat J, Martin-Prevel Y, Martin R, Martorell R, Martos E, Marventano S, Masoodi S, Mathiesen E, Matijasevich A, Matsha T, Mazur A, Mbanya J, McFarlane S, McGarvey S, McKee M, McLachlan S, McLean R, McLean S, McNulty B, Yusof S, Mediene-Benchekor S, Medzioniene J, Meirhaeghe A, Meisfjord J, Meisinger C, Menezes A, Menon G, Mensink G, Meshram I, Metspalu A, Meyer H, Mi J, Michaelsen K, Michels N, Mikkel K, Miller J, Minderico C, Miquel J, Miranda J, Mirkopoulou D, Mirrakhimov E, Mišigoj-Durakovic M, Mistretta A, Mocanu V, Modesti P, Mohamed M, Mohammad K, Mohammadifard N, Mohan V, Mohanna S, Yusoff M, Molbo D, Møllehave L, Møller N, Molnár D, Momenan A, Mondo C, Monterrubio E, Monyeki K, Moon J, Moreira L, Morejon A, Moreno L, Morgan K, Mortensen E, Moschonis G, Mossakowska M, Mostafa A, Mota J, Mota-Pinto A, Motlagh M, Motta J, Mu T, Muc M, Muiesan M, Müller-Nurasyid M, Murphy N, Mursu J, Murtagh E, Musil V, Nabipour I, Nagel G, Naidu B, Nakamura H, Námešná J, Nang E, Nangia V, Nankap M, Narake S, Nardone P, Navarrete-Muñoz E, Neal W, Nenko I, Neovius M, Nervi F, Nguyen C, Nguyen N, Nguyen Q, Nieto-Martínez R, Ning G, Ninomiya T, Nishtar S, Noale M, Noboa O, Norat T, Norie S, Noto D, Nsour M, O'Reilly D, Obreja G, Oda E, Oehlers G, Oh K, Ohara K, Olafsson Ö, Olinto M, Oliveira I, Oltarzewski M, Omar M, Onat A, Ong S, Ono L, Ordunez P, Ornelas R, Ortiz A, Osler M, Osmond C, Ostojic S, Ostovar A, Otero J, Overvad K, Owusu-Dabo E, Paccaud F, Padez C, Pahomova E, Pajak A, Palli D, Palloni A, Palmieri L, Pan W, Panda-Jonas S, Pandey A, Panza F, Papandreou D, Park S, Parnell W, Parsaeian M, Pascanu I, Patel N, Pecin I, Pednekar M, Peer N, Peeters P, Peixoto S, Peltonen M, Pereira A, Perez-Farinos N, Pérez C, Peters A, Petkeviciene J, Petrauskiene A, Peykari N, Pham S, Pierannunzio D, Pigeot I, Pikhart H, Pilav A, Pilotto L, Pistelli F, Pitakaka F, Piwonska A, Plans-Rubió P, Poh B, Pohlabeln H, Pop R, Popovic S, Porta M, Portegies M, Posch G, Poulimeneas D, Pouraram H, Pourshams A, Poustchi H, Pradeepa R, Prashant M, Price J, Puder J, Pudule I, Puiu M, Punab M, Qasrawi R, Qorbani M, Bao T, Radic I, Radisauskas R, Rahman M, Rahman M, Raitakari O, Raj M, Rao S, Ramachandran A, Ramke J, Ramos E, Ramos R, Rampal L, Rampal S, Rascon-Pacheco R, Redon J, Reganit P, Ribas-Barba L, Ribeiro R, Riboli E, Rigo F, de Wit T, Rito A, Ritti-Dias R, Rivera J, Robinson S, Robitaille C, Rodrigues D, Rodríguez-Artalejo F, del Cristo Rodriguez-Perez M, Rodríguez-Villamizar L, Rojas-Martinez R, Rojroongwasinkul N, Romaguera D, Ronkainen K, Rosengren A, Rouse I, Roy J, Rubinstein A, Rühli F, Ruiz-Betancourt B, Russo P, Rutkowski M, Sabanayagam C, Sachdev H, Saidi O, Salanave B, Martinez E, Salmerón D, Salomaa V, Salonen J, Salvetti M, Sánchez-Abanto J, Sandjaja, Sans S, Marina L, Santos D, Santos I, Santos O, dos Santos R, Santos R, Saramies J, Sardinha L, Sarrafzadegan N, Saum K, Savva S, Savy M, Scazufca M, Rosario A, Schargrodsky H, Schienkiewitz A, Schipf S, Schmidt C, Schmidt I, Schultsz C, Schutte A, Sein A, Sen A, Senbanjo I, Sepanlou S, Serra-Majem L, Shalnova S, Sharma S, Shaw J, Shibuya K, Shin D, Shin Y, Shiri R, Siani A, Siantar R, Sibai A, Silva A, Silva D, Simon M, Simons J, Simons L, Sjöberg A, Sjöström M, Skovbjerg S, Slowikowska-Hilczer J, Slusarczyk P, Smeeth L, Smith M, Snijder M, So H, Sobngwi E, Söderberg S, Soekatri M, Solfrizzi V, Sonestedt E, Song Y, Sørensen T, Soric M, Jérome C, Soumare A, Spinelli A, Spiroski I, Staessen J, Stamm H, Starc G, Stathopoulou M, Staub K, Stavreski B, Steene-Johannessen J, Stehle P, Stein A, Stergiou G, Stessman J, Stieber J, Stöckl D, Stocks T, Stokwiszewski J, Stratton G, Stronks K, Strufaldi M, Suárez-Medina R, Sun C, Sundström J, Sung Y, Sunyer J, Suriyawongpaisal P, Swinburn B, Sy R, Szponar L, Tai E, Tammesoo M, Tamosiunas A, Tan E, Tang X, Tanser F, Tao Y, Tarawneh M, Tarp J, Tarqui-Mamani C, Tautu O, Braunerová R, Taylor A, Tchibindat F, Theobald H, Theodoridis X, Thijs L, Thuesen B, Tjonneland A, Tolonen H, Tolstrup J, Topbas M, Topór-Madry R, Tormo M, Tornaritis M, Torrent M, Toselli S, Traissac P, Trichopoulos D, Trichopoulou A, Trinh O, Trivedi A, Tshepo L, Tsigga M, Tsugane S, Tulloch-Reid M, Tullu F, Tuomainen T, Tuomilehto J, Turley M, Tynelius P, Tzotzas T, Tzourio C, Ueda P, Ugel E, Ukoli F, Ulmer H, Unal B, Uusitalo H, Valdivia G, Vale S, Valvi D, van der Schouw Y, Van Herck K, Van Minh H, van Rossem L, Van Schoor N, van Valkengoed I, Vanderschueren D, Vanuzzo D, Vatten L, Vega T, Veidebaum T, Velasquez-Melendez G, Velika B, Veronesi G, Verschuren W, Victora C, Viegi G, Viet L, Viikari-Juntura E, Vineis P, Vioque J, Virtanen J, Visvikis-Siest S, Viswanathan B, Vlasoff T, Vollenweider P, Völzke H, Voutilainen S, Vrijheid M, Wade A, Wagner A, Waldhör T, Walton J, Bebakar W, Mohamud W, Wanderley R, Wang M, Wang Q, Wang Y, Wang Y, Wannamethee S, Wareham N, Weber A, Wedderkopp N, Weerasekera D, Whincup P, Widhalm K, Widyahening I, Wiecek A, Wijga A, Wilks R, Willeit J, Willeit P, Wilsgaard T, Wojtyniak B, Wong-McClure R, Wong J, Wong J, Wong T, Woo J, Woodward M, Wu F, Wu J, Wu S, Xu H, Xu L, Yamborisut U, Yan W, Yang X, Yardim N, Ye X, Yiallouros P, Yngve A, Yoshihara A, You Q, Younger-Coleman N, Yusoff F, Yusoff M, Zaccagni L, Zafiropulos V, Zainuddin A, Zambon S, Zampelas A, Zamrazilová H, Zdrojewski T, Zeng Y, Zhao D, Zhao W, Zheng W, Zheng Y, Zholdin B, Zhou M, Zhu D, Zhussupov B, Zimmermann E, Cisneros J, Bentham J, Di Cesare M, Bilano V, Bixby H, Zhou B, Stevens G, Riley L, Taddei C, Hajifathalian K, Lu Y, Savin S, Cowan M, Paciorek C, Chirita-Emandi A, Hayes A, Katz J, Kelishadi R, Kengne A, Khang Y, Laxmaiah A, Li Y, Ma J, Miranda J, Mostafa A, Neovius M, Padez C, Rampal L, Zhu A, Bennett J, Danaei G, Bhutta Z, Ezzati M. Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. The Lancet 2017, 390: 2627-2642. PMID: 29029897, PMCID: PMC5735219, DOI: 10.1016/s0140-6736(17)32129-3.Peer-Reviewed Original ResearchConceptsMean body mass indexBody mass indexPrevalence of obesitySevere underweightAge-standardised mean body mass indexPrevalence of BMIGlobal age-standardised prevalenceCentral Latin AmericaAge-standardised prevalencePopulation-based studyAdolescent body mass indexAdverse health consequencesNon-significant increaseAndean Latin AmericaBMI categoriesWHO growth referencesMeasurements of heightPooled analysisHigh-income countriesObesityUnderweightHealth programsPrevalenceHealth consequencesGrowth referencesTrends in obesity and diabetes across Africa from 1980 to 2014: an analysis of pooled population-based studies
Kengne A, Bentham J, Zhou B, Peer N, Matsha T, Bixby H, Di Cesare M, Hajifathalian K, Lu Y, Taddei C, Bovet P, Kyobutungi C, Agyemang C, Aounallah-Skhiri H, Assah F, Barkat A, Romdhane H, Chan Q, Chaturvedi N, Damasceno A, Delisle H, Delpeuch F, Doua K, Egbagbe E, Ati J, Elliott P, Engle-Stone R, Erasmus R, Fouad H, Gareta D, Gureje O, Hendriks M, Houti L, Ibrahim M, Kemper H, Killewo J, Kowlessur S, Kruger H, Laamiri F, Laid Y, Levitt N, Lunet N, Magliano D, Maire B, Martin-Prevel Y, Mediene-Benchekor S, Mohamed M, Mondo C, Monyeki K, Mostafa A, Nankap M, Owusu-Dabo E, de Wit T, Saidi O, Schultsz C, Schutte A, Senbanjo I, Shaw J, Smeeth L, Sobngwi E, Jérome C, Stronks K, Tanser F, Tchibindat F, Traissac P, Tshepo L, Tullu F, Ukoli F, Viswanathan B, Wade A, Danaei G, Stevens G, Riley L, Ezzati M, Mbanya J. Trends in obesity and diabetes across Africa from 1980 to 2014: an analysis of pooled population-based studies. International Journal Of Epidemiology 2017, 46: 1421-1432. PMID: 28582528, PMCID: PMC5837192, DOI: 10.1093/ije/dyx078.Peer-Reviewed Original ResearchConceptsMean body mass indexBody mass indexAge-standardized mean body mass indexPopulation-based studyNon-communicable diseasesWorldwide population-based studyAge-standardized prevalenceBurden of diabetesDiabetes prevalence estimatesPopulation-based surveyDiabetes statusDiabetes prevalenceMass indexControl diabetesDiabetes estimatesDiabetesPrevalence estimatesPrevalenceObesityPositive associationWomenSaharan AfricaSexMenHigher number
2015
Mediators of the Effect of Body Mass Index on Coronary Heart Disease
Lu Y, Hajifathalian K, Rimm EB, Ezzati M, Danaei G. Mediators of the Effect of Body Mass Index on Coronary Heart Disease. Epidemiology 2015, 26: 153-162. PMID: 25643095, DOI: 10.1097/ede.0000000000000234.Peer-Reviewed Original ResearchConceptsBody mass indexCoronary heart diseaseExcess relative riskHigh-sensitive C-reactive proteinHigher body mass indexC-reactive proteinBlood pressureRelative riskMass indexBlood glucoseHeart diseaseRisk factorsMetabolic risk factorsProspective cohort studyPrevalence of overweightMajor risk factorRandom-effects modelProthrombotic biomarkersCHD eventsCohort studyInflammatory biomarkersObese participantsMetabolic mediatorsMetabolic factorsMultiplicative scale
2013
Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1·8 million participants
Lu Y, Hajifathalian K, Ezzati M, Woodward M, Rimm E, Danaei G. Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1·8 million participants. The Lancet 2013, 383: 970-983. PMID: 24269108, PMCID: PMC3959199, DOI: 10.1016/s0140-6736(13)61836-x.Peer-Reviewed Original ResearchConceptsBody mass indexCoronary heart diseaseHigher body mass indexHazard ratioBlood pressureExcess riskHeart diseaseEffect of BMIImperial College Healthcare NHS TrustMetabolic risk factorsProspective cohort studyAverage blood pressureHigh blood pressureCardiovascular disease preventionUK Medical Research CouncilNational InstituteRandom-effects modelMedical Research CouncilBiomedical Research CentreCohort studyProspective cohortStroke eventsNormal weightPooled analysisUS National InstitutesThe State of US Health, 1990-2010: Burden of Diseases, Injuries, and Risk Factors
Murray CJ, Atkinson C, Bhalla K, Birbeck G, Burstein R, Chou D, Dellavalle R, Danaei G, Ezzati M, Fahimi A, Flaxman D, Foreman, Gabriel S, Gakidou E, Kassebaum N, Khatibzadeh S, Lim S, Lipshultz SE, London S, Lopez, MacIntyre MF, Mokdad AH, Moran A, Moran AE, Mozaffarian D, Murphy T, Naghavi M, Pope C, Roberts T, Salomon J, Schwebel DC, Shahraz S, Sleet DA, Murray, Abraham J, Ali MK, Atkinson C, Bartels DH, Bhalla K, Birbeck G, Burstein R, Chen H, Criqui MH, Dahodwala, Jarlais, Ding EL, Dorsey ER, Ebel BE, Ezzati M, Fahami, Flaxman S, Flaxman AD, Gonzalez-Medina D, Grant B, Hagan H, Hoffman H, Kassebaum N, Khatibzadeh S, Leasher JL, Lin J, Lipshultz SE, Lozano R, Lu Y, Mallinger L, McDermott MM, Micha R, Miller TR, Mokdad AA, Mokdad AH, Mozaffarian D, Naghavi M, Narayan KM, Omer SB, Pelizzari PM, Phillips D, Ranganathan D, Rivara FP, Roberts T, Sampson U, Sanman E, Sapkota A, Schwebel DC, Sharaz S, Shivakoti R, Singh GM, Singh D, Tavakkoli M, Towbin JA, Wilkinson JD, Zabetian A, Murray, Abraham J, Ali MK, Alvardo M, Atkinson C, Baddour LM, Benjamin EJ, Bhalla K, Birbeck G, Bolliger I, Burstein R, Carnahan E, Chou D, Chugh SS, Cohen A, Colson KE, Cooper LT, Couser W, Criqui MH, Dabhadkar KC, Dellavalle RP, Jarlais, Dicker D, Dorsey ER, Duber H, Ebel BE, Engell RE, Ezzati M, Felson DT, Finucane MM, Flaxman S, Flaxman AD, Fleming T, Foreman, Forouzanfar MH, Freedman G, Freeman MK, Gakidou E, Gillum RF, Gonzalez-Medina D, Gosselin R, Gutierrez HR, Hagan H, Havmoeller R, Hoffman H, Jacobsen KH, James SL, Jasrasaria R, Jayarman S, Johns N, Kassebaum N, Khatibzadeh S, Lan Q, Leasher JL, Lim S, Lipshultz SE, London S, Lopez, Lozano R, Lu Y, Mallinger L, Meltzer M, Mensah GA, Michaud C, Miller TR, Mock C, Moffitt TE, Mokdad AA, Mokdad AH, Moran A, Naghavi M, Narayan KM, Nelson RG, Olives C, Omer SB, Ortblad K, Ostro B, Pelizzari PM, Phillips D, Raju M, Razavi H, Ritz B, Roberts T, Sacco RL, Salomon J, Sampson U, Schwebel DC, Shahraz S, Shibuya K, Silberberg D, Singh JA, Steenland K, Taylor JA, Thurston GD, Vavilala MS, Vos T, Wagner GR, Weinstock MA, Weisskopf MG, Wulf S, Murray. The State of US Health, 1990-2010: Burden of Diseases, Injuries, and Risk Factors. JAMA 2013, 310: 591-606. PMID: 23842577, PMCID: PMC5436627, DOI: 10.1001/jama.2013.13805.Peer-Reviewed Original ResearchConceptsAge-standardized YLL rateHealthy life expectancyBurden of diseaseRisk factorsLife expectancyPopulation healthYLL ratesAge-standardized YLD rateChronic obstructive pulmonary diseaseHigher body mass indexAge-standardized death ratesDeath rateReference life expectancyRisk-outcome pairsSum of YLDsChronic kidney diseaseObstructive pulmonary diseaseHigh blood pressureIschemic heart diseaseBody mass indexLow back painDrug use disordersDisease 2010 studyMajor depressive disorderMajor health problem
2012
A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H, AlMazroa M, Amann M, Anderson H, Andrews K, Aryee M, Atkinson C, Bacchus L, Bahalim A, Balakrishnan K, Balmes J, Barker-Collo S, Baxter A, Bell M, Blore J, Blyth F, Bonner C, Borges G, Bourne R, Boussinesq M, Brauer M, Brooks P, Bruce N, Brunekreef B, Bryan-Hancock C, Bucello C, Buchbinder R, Bull F, Burnett R, Byers T, Calabria B, Carapetis J, Carnahan E, Chafe Z, Charlson F, Chen H, Chen J, Cheng A, Child J, Cohen A, Colson K, Cowie B, Darby S, Darling S, Davis A, Degenhardt L, Dentener F, Jarlais D, Devries K, Dherani M, Ding E, Dorsey E, Driscoll T, Edmond K, Ali S, Engell R, Erwin P, Fahimi S, Falder G, Farzadfar F, Ferrari A, Finucane M, Flaxman S, Fowkes F, Freedman G, Freeman M, Gakidou E, Ghosh S, Giovannucci E, Gmel G, Graham K, Grainger R, Grant B, Gunnell D, Gutierrez H, Hall W, Hoek H, Hogan A, Hosgood H, Hoy D, Hu H, Hubbell B, Hutchings S, Ibeanusi S, Jacklyn G, Jasrasaria R, Jonas J, Kan H, Kanis J, Kassebaum N, Kawakami N, Khang Y, Khatibzadeh S, Khoo J, Kok C, Laden F, Lalloo R, Lan Q, Lathlean T, Leasher J, Leigh J, Li Y, Lin J, Lipshultz S, London S, Lozano R, Lu Y, Mak J, Malekzadeh R, Mallinger L, Marcenes W, March L, Marks R, Martin R, McGale P, McGrath J, Mehta S, Memish Z, Mensah G, Merriman T, Micha R, Michaud C, Mishra V, Hanafiah K, Mokdad A, Morawska L, Mozaffarian D, Murphy T, Naghavi M, Neal B, Nelson P, Nolla J, Norman R, Olives C, Omer S, Orchard J, Osborne R, Ostro B, Page A, Pandey K, Parry C, Passmore E, Patra J, Pearce N, Pelizzari P, Petzold M, Phillips M, Pope D, Pope C, Powles J, Rao M, Razavi H, Rehfuess E, Rehm J, Ritz B, Rivara F, Roberts T, Robinson C, Rodriguez-Portales J, Romieu I, Room R, Rosenfeld L, Roy A, Rushton L, Salomon J, Sampson U, Sanchez-Riera L, Sanman E, Sapkota A, Seedat S, Shi P, Shield K, Shivakoti R, Singh G, Sleet D, Smith E, Smith K, Stapelberg N, Steenland K, Stöckl H, Stovner L, Straif K, Straney L, Thurston G, Tran J, Van Dingenen R, van Donkelaar A, Veerman J, Vijayakumar L, Weintraub R, Weissman M, White R, Whiteford H, Wiersma S, Wilkinson J, Williams H, Williams W, Wilson N, Woolf A, Yip P, Zielinski J, Lopez A, Murray C, Ezzati M. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet 2012, 380: 2224-2260. PMID: 23245609, PMCID: PMC4156511, DOI: 10.1016/s0140-6736(12)61766-8.Peer-Reviewed Original ResearchConceptsSecond-hand smokeDisease Study 2010High blood pressureRisk factorsDisease burdenGlobal disease burdenTobacco smokingRisk factor exposureBlood pressureGlobal DALYsChildhood underweightRelative riskGlobal burdenStudy 2010Unimproved waterCommunicable diseasesHigher body mass indexHigh-income North AmericaAlcohol useChildhood communicable diseasesDisability-adjusted life yearsRisk factor clustersDietary risk factorsCause-specific deathBody mass index
2011
National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants
Finucane MM, Stevens GA, Cowan MJ, Danaei G, Lin JK, Paciorek CJ, Singh GM, Gutierrez HR, Lu Y, Bahalim AN, Farzadfar F, Riley LM, Ezzati M, Group O. National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants. The Lancet 2011, 377: 557-567. PMID: 21295846, PMCID: PMC4472365, DOI: 10.1016/s0140-6736(10)62037-5.Peer-Reviewed Original ResearchConceptsBody mass indexHealth Examination SurveyHigher body mass indexFemale body mass indexMale body mass indexExamination SurveyEpidemiological studiesPopulation body mass indexMean body mass indexMajor public health concernNational Health Examination SurveyAdults 20 yearsPublic health concernNon-significant decreaseBMI changeExcess bodyweightMetabolic mediatorsHigh-income countriesHealth concernMelinda Gates FoundationHealth effectsWomenMenSaharan AfricaGates Foundation