The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy
Dong Z, Liu Z, Dai H, Liu W, Feng Z, Zhao Q, Gao Y, Liu F, Zhang N, Dong X, Zhou X, Du J, Huang G, Tian X, Liu B. The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy. Journal Of Immunology Research 2020, 2020: 7638365. PMID: 33426094, PMCID: PMC7772048, DOI: 10.1155/2020/7638365.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsIdiopathic membranous nephropathyRegulatory B cellsBreg cellsMembranous nephropathyImmune responseB cellsPathogenesis of IMNDifferent inflammatory environmentsFunction of BregsPathological autoimmune responsesRole of BregsCellular immune responsesHumoral immune responseIMN patientsImmunomodulatory cellsImmunosuppressive roleAutoimmune responseInterleukin-10Autoimmune diseasesImmune cellsInflammatory environmentEarly treatmentT cellsBregsImmunological phenomenaIdiopathic Membranous Nephropathy: Glomerular Pathological Pattern Caused by Extrarenal Immunity Activity
Liu W, Gao C, Liu Z, Dai H, Feng Z, Dong Z, Zheng Y, Gao Y, Tian X, Liu B. Idiopathic Membranous Nephropathy: Glomerular Pathological Pattern Caused by Extrarenal Immunity Activity. Frontiers In Immunology 2020, 11: 1846. PMID: 33042109, PMCID: PMC7524879, DOI: 10.3389/fimmu.2020.01846.BooksMeSH KeywordsAutoantibodiesAutoantigensGlomerulonephritis, MembranousHumansModels, ImmunologicalPodocytesConceptsIdiopathic membranous nephropathyGlomerular lesionsThrombospondin type-1 domain-containing 7APathological patternsImmune complex depositionDevelopment of proteinuriaM-type receptorNeural epidermal growthSecretory phospholipase A2Glomerular basement membraneIgG4 predominanceProteinuria remissionCirculating AntibodiesClinical featuresGlomerular damageMembranous nephropathySpontaneous remissionAutoimmune responseComplex depositionExtrarenal tissuesImmune activityAutoimmunity initiationClinical practicePathogenesis modelTHSD7A antigen