2022
Podocyte Endocytosis in Regulating the Glomerular Filtration Barrier
Tian X, Bunda P, Ishibe S. Podocyte Endocytosis in Regulating the Glomerular Filtration Barrier. Frontiers In Medicine 2022, 9: 801837. PMID: 35223901, PMCID: PMC8866310, DOI: 10.3389/fmed.2022.801837.Peer-Reviewed Original ResearchPlasma membrane componentsHuman genetic mutationsGlomerular filtration barrierEndocytosis genesEndocytic machineryFiltration barrierTransmembrane receptorsBiological functionsVesicle formationSignaling pathwaysEndocytosisMembrane componentsPodocyte functionCellular endocytosisNovel insightsProteinuric glomerular diseasesAdjacent basement membraneGenetic mutationsFunction studiesEpithelial cellsPathwayEndothelial cell layerBasement membraneImportant roleCell layer
2020
Murine Epsins Play an Integral Role in Podocyte Function
Wang Y, Pedigo CE, Inoue K, Tian X, Cross E, Ebenezer K, Li W, Wang Z, Shin JW, Schwartze E, Groener M, Ishibe S. Murine Epsins Play an Integral Role in Podocyte Function. Journal Of The American Society Of Nephrology 2020, 31: 2870-2886. PMID: 33051360, PMCID: PMC7790213, DOI: 10.1681/asn.2020050691.Peer-Reviewed Original ResearchConceptsSerum response factorPodocyte-specific lossCell division control protein 42 homologCell adhesionRegulation of Cdc42Integrin expressionProtein Cdc42Membrane proteinsTriple knockout miceEpsinDownstream regulationFoot process effacementPodocyte functionResponse factorPrimary podocytesCdc42Essential roleIndispensable roleProcess effacementExpressionRegulationKnockout miceIntegral rolePodocytesHomolog