2023
VPA improves ferroptosis in tubular epithelial cells after cisplatin-induced acute kidney injury
Li Y, Li K, Zhao W, Wang H, Xue X, Chen X, Li W, Xu P, Wang K, Liu P, Tian X, Fu R. VPA improves ferroptosis in tubular epithelial cells after cisplatin-induced acute kidney injury. Frontiers In Pharmacology 2023, 14: 1147772. PMID: 37153759, PMCID: PMC10155836, DOI: 10.3389/fphar.2023.1147772.Peer-Reviewed Original ResearchCisplatin-induced acute kidney injuryAcute kidney injuryAcyl-CoA synthetase long-chain family member 4Valproic acidKidney injuryTubular epithelial cellsGlutathione peroxidase 4Renal injuryDownregulation of GPX4Cisplatin-induced AKI miceCisplatin-induced renal injuryFer-1 treatmentEpithelial cellsBlood urea nitrogenCell deathFamily member 4AKI miceSerum creatinineAntiepileptic drugsHistone deacetylase 1Protective effectUrea nitrogenViable treatmentTissue damageCisplatin treatment
2022
Coronavirus Lung Infection Impairs Host Immunity against Secondary Bacterial Infection by Promoting Lysosomal Dysfunction.
Peng X, Kim J, Gupta G, Agaronyan K, Mankowski MC, Korde A, Takyar SS, Shin HJ, Habet V, Voth S, Audia JP, Chang D, Liu X, Wang L, Cai Y, Tian X, Ishibe S, Kang MJ, Compton S, Wilen CB, Dela Cruz CS, Sharma L. Coronavirus Lung Infection Impairs Host Immunity against Secondary Bacterial Infection by Promoting Lysosomal Dysfunction. The Journal Of Immunology 2022, 209: 1314-1322. PMID: 36165196, PMCID: PMC9523490, DOI: 10.4049/jimmunol.2200198.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Bacterial infectionsMouse modelCoronavirus infectionLysosomal dysfunctionMajor health care challengeLung immune cellsLung tissue damageSecondary bacterial infectionImpair host immunityIL-1β releaseHealth care challengesCell deathPyroptotic cell deathBacterial killing abilityIL-1βBacterial clearanceImmune cellsSecondary infectionHost immunityAlveolar macrophagesTissue damageΒ-coronavirusStructural cellsCare challenges