2022
Increased Expression of LEF1 and β-Catenin in Invasive Micropapillary Carcinoma of the Breast is Associated With Lymphovascular Invasion and Lymph Node Metastasis
Dolezal D, Zhang X, Harigopal M. Increased Expression of LEF1 and β-Catenin in Invasive Micropapillary Carcinoma of the Breast is Associated With Lymphovascular Invasion and Lymph Node Metastasis. Applied Immunohistochemistry & Molecular Morphology 2022, 30: 557-565. PMID: 35960138, DOI: 10.1097/pai.0000000000001052.Peer-Reviewed Original ResearchConceptsInvasive micropapillary breast carcinomaLymph node metastasisLymphoid enhancer-binding factor 1Lymphovascular invasionNode metastasisNodal metastasisPrimary tumorΒ-cateninBreast tumorsRare breast cancer subtypeSmall tumor cell clustersLEF1 expressionMicropapillary breast carcinomaAggressive breast tumorsBasal-like carcinomasInvasive micropapillary carcinomaΒ-catenin expression levelsBreast cancer subtypesΒ-catenin expressionTumor cell clustersEnhancer-binding factor 1Disease relapseMicropapillary carcinomaBreast carcinomaHigh incidence
2021
Calcifying nested stromal–epithelial tumor: a clinicopathologic and molecular genetic study of eight cases highlighting metastatic potential and recurrent CTNNB1 and TERT promoter alterations
Papke Jr. D, Dong F, Zhang X, Kozielski R, Basturk O, Fletcher CDM, Zhao L. Calcifying nested stromal–epithelial tumor: a clinicopathologic and molecular genetic study of eight cases highlighting metastatic potential and recurrent CTNNB1 and TERT promoter alterations. Modern Pathology 2021, 34: 1696-1703. PMID: 33994539, DOI: 10.1038/s41379-021-00822-w.Peer-Reviewed Original ResearchConceptsStromal-epithelial tumorTERT promoter mutationsMetastatic diseaseCTNNB1 alterationsRare hepatic tumorRecurrent liver tumorsTERT promoter alterationsMedian tumor sizePromoter mutationsMolecular genetic featuresNuclear β-catenin expressionΒ-catenin expressionNeoadjuvant chemotherapyAbdominal metastasesLatter patientsLymphovascular invasionMedian ageLung metastasesTumor sizeHepatic tumorsNeuroendocrine markersEosinophilic cytoplasmLiver tumorsFibrous stromaTumor fibrosis