Progressive recruitment of Runx2 to genomic targets despite decreasing expression during osteoblast differentiation
Pregizer S, Baniwal SK, Yan X, Borok Z, Frenkel B. Progressive recruitment of Runx2 to genomic targets despite decreasing expression during osteoblast differentiation. Journal Of Cellular Biochemistry 2008, 105: 965-970. PMID: 18821584, PMCID: PMC2591066, DOI: 10.1002/jcb.21900.Peer-Reviewed Original ResearchConceptsOC promoterGenomic targetsOsteoblast differentiationNovel genomic targetsChIP-chip analysisChromatin immunoprecipitation assaysDNA-binding abilityDNA-binding activityOsteoblast transcription factorSuch stringent controlTranscriptional controlMRNA levelsTranslational controlTranscription factorsImmunoprecipitation assaysMC3T3-E1 culturesRunx2 mRNA levelsOC mRNA levelsOsteoblast phenotypeRunx2 mRNAPromoterRunx2Protein amountOC expressionStringent control