Signaling through the Adaptor Molecule MyD88 in CD4+ T Cells Is Required to Overcome Suppression by Regulatory T Cells
Schenten D, Nish SA, Yu S, Yan X, Lee HK, Brodsky I, Pasman L, Yordy B, Wunderlich FT, Brüning JC, Zhao H, Medzhitov R. Signaling through the Adaptor Molecule MyD88 in CD4+ T Cells Is Required to Overcome Suppression by Regulatory T Cells. Immunity 2014, 40: 78-90. PMID: 24439266, PMCID: PMC4445716, DOI: 10.1016/j.immuni.2013.10.023.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityAnimalsCells, CulturedImmunity, InnateImmunologic MemoryImmunosuppression TherapyInterleukin-1Interleukin-18MiceMice, Inbred C57BLMice, TransgenicMyeloid Differentiation Factor 88Organ SpecificityReceptors, Interleukin-1Signal TransductionTh1 CellsTh17 CellsT-Lymphocytes, RegulatoryConceptsToll-like receptorsTh1 cell responsesT cellsCell-specific ablationCell responsesIL-1Interleukin-1 receptor family memberT helper 17 (Th17) cell responsesTreg cell-mediated suppressionTreg cell-specific ablationT cell-specific ablationRegulatory T cellsT regulatory (Treg) cellsCell-mediated suppressionMemory T cellsAdaptor molecule MyD88Adaptive immune responsesIL-1 actsTreg cellsRegulatory cellsReceptor family membersMolecule MyD88Th1 cellsImmune responseMyD88T cell-intrinsic role of IL-6 signaling in primary and memory responses
Nish SA, Schenten D, Wunderlich FT, Pope SD, Gao Y, Hoshi N, Yu S, Yan X, Lee HK, Pasman L, Brodsky I, Yordy B, Zhao H, Brüning J, Medzhitov R. T cell-intrinsic role of IL-6 signaling in primary and memory responses. ELife 2014, 3: e01949. PMID: 24842874, PMCID: PMC4046568, DOI: 10.7554/elife.01949.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityAnimalsCD4-Positive T-LymphocytesCells, CulturedCoculture TechniquesDose-Response Relationship, DrugImmunity, InnateImmunizationImmunologic MemoryInterleukin-1betaInterleukin-6Interleukin-6 Receptor alpha SubunitMice, Inbred C57BLMice, KnockoutOvalbuminRecombinant ProteinsSignal TransductionTh1 CellsTh17 CellsT-Lymphocytes, RegulatoryConceptsIL-6T cellsIL-6 receptor α chainT cell memory formationT cell-intrinsic roleAbsence of TregsDepletion of TregsPrimary Th1 responseEffector T cellsT cell responsesFunctional memory cellsAdaptive immune responsesT cell-specific deletionInnate immune recognitionCell-intrinsic roleCell-specific deletionReceptor α chainTfh functionTh1 responseTh17 responsesIL-1βIL-2Immune responseTregsSuppressive effect