Featured Publications
Transcriptomics of bronchoalveolar lavage cells identifies new molecular endotypes of sarcoidosis
Vukmirovic M, Yan X, Gibson KF, Gulati M, Schupp JC, DeIuliis G, Adams TS, Hu B, Mihaljinec A, Woolard TN, Lynn H, Emeagwali N, Herzog EL, Chen ES, Morris A, Leader JK, Zhang Y, Garcia JGN, Maier LA, Collman RG, Drake WP, Becich MJ, Hochheiser H, Wisniewski SR, Benos PV, Moller DR, Prasse A, Koth LL, Kaminski N. Transcriptomics of bronchoalveolar lavage cells identifies new molecular endotypes of sarcoidosis. European Respiratory Journal 2021, 58: 2002950. PMID: 34083402, PMCID: PMC9759791, DOI: 10.1183/13993003.02950-2020.Peer-Reviewed Original ResearchConceptsWeighted gene co-expression network analysisGene co-expression network analysisCo-expression network analysisGene expression programsGene expression patternsDistinct transcriptional programsImmune response pathwaysIon Torrent ProtonMicroarray expression datasetsExpression programsTranscriptional programsPhenotypic traitsGene modulesResponse pathwaysRNA sequencingMolecular endotypesExpression patternsGene expressionHilar lymphadenopathyOrgan involvementGenomic researchMechanistic targetExpression datasetsT helper type 1T cell immune responses
2008
Nonlinear cooperation of p53-ING1-induced bax expression and protein S-nitrosylation in GSNO-induced thymocyte apoptosis: a quantitative approach with cross-platform validation
Duan S, Wan L, Fu WJ, Pan H, Ding Q, Chen C, Han P, Zhu X, Du L, Liu H, Chen Y, Liu X, Yan X, Deng M, Qian M. Nonlinear cooperation of p53-ING1-induced bax expression and protein S-nitrosylation in GSNO-induced thymocyte apoptosis: a quantitative approach with cross-platform validation. Apoptosis 2008, 14: 236. PMID: 19082896, DOI: 10.1007/s10495-008-0288-4.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnimalsApoptosisBcl-2-Associated X ProteinDexamethasoneGene DosageGene Expression RegulationInhibitor of Growth Protein 1Intracellular Signaling Peptides and ProteinsMiceModels, BiologicalNeural Networks, ComputerNonlinear DynamicsNuclear ProteinsOligonucleotide Array Sequence AnalysisProtein BindingReproducibility of ResultsReverse Transcriptase Polymerase Chain ReactionS-NitrosoglutathioneThymus GlandTumor Suppressor Protein p53Tumor Suppressor Proteins