2008
A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity
Negishi H, Osawa T, Ogami K, Ouyang X, Sakaguchi S, Koshiba R, Yanai H, Seko Y, Shitara H, Bishop K, Yonekawa H, Tamura T, Kaisho T, Taya C, Taniguchi T, Honda K. A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 20446-20451. PMID: 19074283, PMCID: PMC2629334, DOI: 10.1073/pnas.0810372105.Peer-Reviewed Original ResearchConceptsToll-like receptor 3Toll-like receptorsType II IFNImmune responseNucleic acid-sensing Toll-like receptorsReceptor 3Innate antiviral immune responseAntiviral innate immune responseTLR3-deficient miceType I IFN responseAntiviral immune responseAntiviral innate immunityInnate immune responseI IFN responseInnate antiviral immunityType II interferonAcute myocarditisVirus infectionAntiviral immunityI IFNMouse resistanceInnate immunityTypes of virusesIFN responseIFNEpstein‐Barr virus‐induced gene 3 negatively regulates IL‐17, IL‐22 and RORγt
Yang J, Yang M, Htut TM, Ouyang X, Hanidu A, Li X, Sellati R, Jiang H, Zhang S, Li H, Zhao J, Ting AT, Mayer L, Unkeless JC, Labadia ME, Hodge M, Li J, Xiong H. Epstein‐Barr virus‐induced gene 3 negatively regulates IL‐17, IL‐22 and RORγt. European Journal Of Immunology 2008, 38: 1204-1214. PMID: 18412165, PMCID: PMC2989250, DOI: 10.1002/eji.200838145.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD4-Positive T-LymphocytesCell DifferentiationForkhead Transcription FactorsGene ExpressionGene Expression RegulationInterferon-gammaInterleukin-17InterleukinsListeria monocytogenesListeriosisMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMinor Histocompatibility AntigensNuclear Receptor Subfamily 1, Group F, Member 3OvalbuminReceptors, Antigen, T-CellReceptors, Retinoic AcidReceptors, Thyroid HormoneSpleenT-LymphocytesT-Lymphocytes, RegulatoryTumor Necrosis Factor-alphaConceptsIL-17IL-22Th17 cellsIL-27Spleen cellsRORgamma tEpstein-Barr virus-induced gene 3IL-17-producing cellsReduced bacterial loadIL-35Protective immunityIL-12p35Th17 conditionsAdaptive immunityEBI3Mouse studiesL. monocytogenesBacterial loadMiceElevated levelsAcute challengeGene 3High levelsP28Immunity
2006
Evidence for licensing of IFN-γ-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program
Negishi H, Fujita Y, Yanai H, Sakaguchi S, Ouyang X, Shinohara M, Takayanagi H, Ohba Y, Taniguchi T, Honda K. Evidence for licensing of IFN-γ-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 15136-15141. PMID: 17018642, PMCID: PMC1586247, DOI: 10.1073/pnas.0607181103.Peer-Reviewed Original ResearchConceptsTranscription factorsTarget genesIFN regulatory factor (IRF) familyToll-like receptorsFactor-1 transcription factorRegulatory factor familyIFN-gammaTransduction pathwaysFactor familyTLR-MyD88 pathwayAdditional membersMicrobial componentsIRF1Mechanistic insightsMyD88 adaptorInducible NO synthaseGenesCritical roleTLR signalingPathwayIL-12p35TLR activationNO synthaseIFN-betaMyD88